Abstract
Recently we investigated 29 patients aged between 31 and 60 years with multiple sclerosis by means of two new techniques. The first technique was based on pupillary dilatation response to the topical application of the cholinergic antagonist tropicamide. The second technique was the Fourier analysis of pupillary oscillations for measurement of central activation, carried out without and under the influence of a cognitive task. The multiple sclerosis group had a pupillary dilatation of 31.9% after 40 min. Under the influence of a cognitive task the patient group revealed lower amplitudes of pupillary oscillations reflecting a decreased capacity for cognitive activation.
Similar content being viewed by others
References
Grünberger J, Linzmayer L, Grünberger M, Saletu B (1992) Pupillometry in clinical psychophysiological diagnostics: methodology and proposals for application in psychiatry. Isr J Psychiatry Relat Sci 28 (2):100–113
Grünberger J, Linzmayer L, Grünberger M, Saletu B (1994) Eine neue methode zur Messung der zentralen Aktivierung: Fourieranalyse der Pupillenoszillationen bei depressiven Patienten. Wien Klin Wochenschr 106(6):164–170
Grünberger J, Linzmayer L, Wytek R, Grünberger M (1996) Die kognitive Pupillenoszillationshypothese bei Patienten mit neurotischen Persönlichkeitsstörungen und organischem Psychosyndrom. Wien Klin Wochenschr 108/3:69–74
Schandry R (1981) Psychophysiologie. Körperliche Indikatoren menschlichen Verhaltens. Urban and Schwarzenberg, München
Scinto LFM, Daffner KR, Dressler D, Ransil BI, Rentz D, Weintraub S, Mesulam M, Potter H (1994) A potential noninvasive neurobiological test for Alzheimer's disease. Science 266 (5187): 1051–1054
Scinto LFM, Daffner KR, Dressler D, Rentz D, Ransil BI, Potter H (1995) Hypersensitive pupillary dilatation to a cholinergic antagonist as a diagnostic test for Alzheimer's disease. In: Iqbal K, Mortimer JA, Winblad D, Wisniewski HH (eds) Research advances in Alzheimer's disease and related disorders. Wiley, New York, pp 161–172
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Grünberger, J., Linzmayer, L., Majda, E.M. et al. Pupillary dilatation test and Fourier analysis of pupillary oscillations in patients with multiple sclerosis. Eur Arch Psychiatry Clin Nuerosci 246, 209–212 (1996). https://doi.org/10.1007/BF02188955
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02188955