Lack of association between schizophrenia and the apolipoprotein E ε4 allele

  • E. Jönsson
  • G. Sedvall
  • L. Lannfelt
  • B. Engvall
Original Paper


The association between the ε4 allele of the apolipoprotein E (APOE) gene and Alzheimer's disease (AD) has been reported. In order to examine if the ε4 allele may play a role also in schizophrenia, another mental disorder, patients (n=87) and control subjects (n=57) were genotyped for APOE. No significant difference was found between the groups. The data indicate that the APOE gene is not of major importance for the genesis of schizophrenia.

Key words

Schizophrenia Apolipoprotein E Association study Psychiatric genetics Alzheimer's disease 


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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • E. Jönsson
    • 1
  • G. Sedvall
    • 1
  • L. Lannfelt
    • 2
  • B. Engvall
    • 2
  1. 1.Department of Clinical Neuroscience, Psychiatry SectionKarolinska InstituteStockholmSweden
  2. 2.Department of Geriatric MedicineHuddinge HospitalHuddingeSweden

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