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International Journal of Biometeorology

, Volume 31, Issue 3, pp 191–199 | Cite as

Effect of demedullation on freezing injury in hind limbs of rats

  • Shashi Dhingra
  • B. Bhatia
  • G. S. Chhina
  • Baldev Singh
Article
  • 25 Downloads

Abstract

Freezing incidence and tissue loss on exposure of hind limbs of female Wistar rats to freezing mixture was reduced by demedullation 6 days prior to cold exposure (p<0.01 and p<0.001 respectively); demedullation 1 h after freezing injury had no effect on tissue loss. Noradrenaline (1 mg/kg i.p.) 5 min before exposure increased the freezing incidence in intact (p<0.05) as well as in demedullated rats (p<0.01), with no effect on tissue loss. Adrenaline (500 mg/kg i.p.) had no effect on either. A sustained fall in plasma adrenaline after demedullation leading to reduced reactivity of the blood vessels to some vasoactive agents is postulated.

Keywords

Blood Vessel Plant Physiology Noradrenaline Adrenaline Hind Limb 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Swets & Zeitlinger 1987

Authors and Affiliations

  • Shashi Dhingra
    • 1
  • B. Bhatia
    • 2
  • G. S. Chhina
    • 3
  • Baldev Singh
    • 3
  1. 1.School of Environmental SciencesJawaharlal Nehru UniversityNew DelhiIndia
  2. 2.Environmental and Nutritional Health Research OrganisationNew DelhiIndia
  3. 3.Department of PhysiologyAll-India Institute of Medical SciencesNew DelhiIndia

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