Abstract
An account is given of the annual variation in composition andin vitro anti-HIV-1 activity of the water-soluble sulfated glucuronogalactan fromSchizymenia dubyi collected in Sicily. No marked variation seasonal chemical or physico-chemical features was observed, with the exception of L-galactose residues and viscosity. Evaluation of the anti-HIV-1 effect of the polysaccharide indicated that syncitial formation and HIV-associated reverse transcriptasein vitro were completely suppressed at 5 μg ml−1 by alga collected during the summer/spring period. This high anti-HIV-1 activity corresponded with a decrease in L-galactose, viscosity and sulfate content of the polysaccharide.
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Bourgougnon, N., Lahaye, M., Quemener, B. et al. Annual variation in composition andin vitro anti-HIV-1 activity of the sulfated glucuronogalactan fromSchizymenia dubyi (Rhodophyta, Gigartinales). J Appl Phycol 8, 155–161 (1996). https://doi.org/10.1007/BF02186319
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DOI: https://doi.org/10.1007/BF02186319