Advertisement

International Journal of Biometeorology

, Volume 26, Issue 2, pp 121–128 | Cite as

Environmental factors affecting seasonal variation in immunity of clinically normal dogs

  • A. Garsd
  • M. Shifrine
Article

Abstract

A whole blood lymphocyte stimulation test, an in vitro corollary of in vivo cell mediated immunity, was done with blood collected monthly from eleven dogs for a period of three years (August, 1977 through August, 1980). Seasonal variations in immunity were observed to occur. These fluctuations were analyzed for possible association with 22 environmental, solar, and meteorological parameters. Of the six independent variables significantly entering the predictive regression equations, sunspot activity (monthly mean daily number of sunspots) was most prominent, showing a significant negative correlation in 10 of the 11 dogs. This suggests that solar activity might be associated with some activity on earth, e.g., geomagnetism which in turn might affect immune response.

Keywords

Immune Response Negative Correlation Plant Physiology Seasonal Variation Solar Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. DANIEL, C. and WOOD, F. S. (1980): Fitting Equations to Data. J. Wiley and Sons, New York, 458 pp.Google Scholar
  2. DIXON, W. J. and BROWN, M. B. (1979): All Possible Subsets Regression, Biomedical Computer Programs P-series. University of California Press, Los Angeles, p. 418–436.Google Scholar
  3. DUBROV, A. P. (1978): The Geomagnetic GField and Life. Geomagnetobiology. Plenum Press, New York, 318 pp.Google Scholar
  4. GNEVYSHEV, M. N. and OL', A. I. (1971): Effects of Solar Activity on the Earth's Atmosphere and Biosphere. English translation by Keter Publishing House, Jerusalem, 290 pp.Google Scholar
  5. HERMAN, J. R. and GOLDBERG, R. A. (1978): Sun, Weather, and Climate. National Aeronautics and Space Administration, Washington DC, 360 pp.Google Scholar
  6. HOCKING, R. R. (1976): The analysis and selection of variables in linear regression. Biometrics, 52: 1–49.Google Scholar
  7. HOPE-SIMPSON, R. E. (1978): Sunspots and flu: A correlation. Nature (Lond.), 275: 86.Google Scholar
  8. MCKELVIE, D. H. and ANDERSEN, A. C. (1966): Production and care of laboratory beagles. J. Inst. Animal Tech., 17: 25–33.Google Scholar
  9. MOMENI, H. H., WORDEN, L., and GOLDMAN, M. (1974): Dosimetry and facilities of UCD outdoor-indoor60Co irradiation. Health Phys., 26:469–472.PubMedGoogle Scholar
  10. SHIFRINE, M., TAYLOR, N. J., ROSENBLATT, L. S., and WILSON, F. D. (1978): Comparison of whole blood and purified canine lymphocytes in a lymphocyte-stimulation microassay. Amer. J. Vet. Res., 39: 687–690.PubMedGoogle Scholar
  11. SHIFRINE, M., TAYLOR, N., ROSENBLATT, L. S., and WILSON, F. D. (1980a): Seasonal variation in cell mediated immunity of clinically normal dogs. Exp. Hematol., 8: 318–326.PubMedGoogle Scholar
  12. SHIFRINE, M., ROSENBLATT, L. S., TAYLOR, N., HETHERINGTON, N. W., MATTHEWS, V. J., and WILSON, F. D. (1980b): Seasonal variations in lectin-induced lymphocyte transformation in beagle dogs. J. Interdisipl. cycle Res., 11: 219–231.Google Scholar
  13. SHIFRINE, M., GARSD, A., CHRISTIANSEN, J., and ROSENBLATT, L. S. (1982): Photoperiod and cell mediated immunity of clinically normal dogs. J. Interdiscipl. Cycle Res., 13: 177–186.Google Scholar
  14. THILSTED, J. P., SHIFRINE, M., and WIGER, N. (1979): Correlation of in vitro and in vivo tests for cell-mediated immunity in the dog. Amer. J. Vet. Res., 40: 1312–1315.Google Scholar

Copyright information

© Swets & Zeitlinger B.V. 1982

Authors and Affiliations

  • A. Garsd
    • 1
  • M. Shifrine
    • 1
  1. 1.Laboratory for Energy-Related Health ResearchUniversity of CaliforniaDavisUSA

Personalised recommendations