The effects of exposure to various degrees of heat stress on serum glutamate—oxaloacetate transaminase (SGOT), serum glutamate-pyruvate transaminase (SGPT), alkaline phosphatase (ALK-P-ase), calcium and chlorides have been studied on 75 dogs. Rectal temperature (Tre) was recorded before and after exposure to heat stress. These dogs were divided into 5 groups, according to the Tre level attained after exposure to heat stress. Rectal temperature was raised from normal to 39.45±0.47‡C in the first group, to 40.93±0.17‡C in the second group, to 41.87±0.22‡C in the third group, to 42.90 ± 0.21‡C in the fourth group and to 43.93±0.19‡C in the fifth group. The concentration of enzymes SGOT, SGPT and ALK-P-ase in blood and cerebrospinal fluid (CSF) increased significantly with hyperthermia. Calcium and chlorides concentrations in blood and in CSF tended to increase in hyperthermia. The integrity of the blood brain barrier for these enzymes and calcium is maintained under mild hyperthermia but it breaks down partially under influence of more severe hyperthermia. Core temperature above 41‡C results in damage to tissues and consequential rise of plasma enzymes. This degree of hyperthermia also seems to mark the beginning of injury to blood brain barrier. Critical core temperature tolerated by 50% of animals was 44‡C.
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AGARWAL, N. L. (1962): Evaluation of functional and morphological status of liver during pyrexia. Thesis for M.D. (Medicine), Lucknow University.
AUSTIN, M. G. and BERRY, J. W. (1956): Observations on 100 cases of heat stroke. J. Amer. med. Ass., 161: 1525–1529.
BONNER, R. M., HARRISON, M. H., HALL, C. J. and EDWARD, R. J. (1976): Effect of heat acclimatization on intravascular responses to heat stress in man. J. appl. Physiol., 41: 708–713.
BRAGDON, J. H. (1947): The hepatitis of hyperthermia. New Eng. J. Med., 237: 765–769.
GISOLFI, C. V., MORA, F. and MYERS, R. D. (1977): Diencephalic efflux of calcium ions in monkey during exercise, thermal stress and feeding. J. Physiol. (Lond.), 273: 617–629.
GISOLFI, C. V., WILSON, N. C., MYERS, R. D. and PHILLIPS, M. I. (1976): Exercise thermoregulation: hypothalamic perfusion of excess calcium reduces elevated colonic temperature of rats. Brain Res., 101: 160–164.
GORE, I. and ISAACSON, N. H. (1949): The pathology of hyperpyrexia, observations at autopsy in 17 cases of fever therapy. Amer. J. Path., 25: 1029–1059.
GREENLEAF, J. E., KOLZOWSKI, S., NAZAR, K., KACIUBA-USCILKO, H., BRZESINKSKA, Z. and ZIEMBA, A. (1976): Ion-osmotic hyperthermia during exercise in dogs. Amer. J. Physiol., 230: 74–79.
HASAMA, B. (1930): Pharmakologische und physiologische Studien über die Schweisszentren. Arch. expl. Path. Pharmak; 153: 291–308.
HERMANN, R. H. and SULLIVAN, B. H. (1959): Heat stroke and jaundice. Amer. J. Med., 27: 154–166.
HOFFMAN, W. S. (1970): The Biochemistry of Clinical Medicine. Year Book Medical Publishers, INC, Chicago, 413 pp.
KOSUNEN, K. J., PAKARINEN, A. J., KUOPPASALMI, K. and ADLERCREUTZ, H. (1976): Plasma renin activity, angiotensin II and aldosterone during intense heat stress. J. appl. Physiol., 41: 323–327.
KYM, O. (1934): Die Beeinflussung des durch verschiedene fiebererzeugende Stoffe erregten Temperaturzentrums durch lokale Applikation von Ca, K und Na. Arch. exp. Path. Pharmak., 176: 408–424.
MALAMUD, N., HAYMAKER, W. and CUSTER, R. P. (1946): Heat stroke: A. clinicopathological study of 125 fatal cases. Milit. Surg., 99: 397–449.
MEHROTRA, R. M. L. and KANTHASWAMY, V. (1962): An experimental study of hepatic injury in hyperthermia. Ind. J. Path. Bact., 5: 186–197.
MYERS, R. D. (1976): Diencephalic efflux of Na+ and Ca++ ions in febrile Cat: effect of an antipyretic. Brain Res., 103: 412–417.
MYERS, R. D. and TYTELL, M. (1972): Fever: reciprocal shift in brain sodium to calcium ratio as the set point temperature rises. Science, 178: 765–767.
MYERS, R. D. and VEALE, W. L. (1970): Body temperature: possible ionic mechanism in the hypothalamus controlling the set point. Science, 170: 95–97.
NIELSEN, B., SCHWARTZ, P. and ALHEDE, J. (1973): Is fever in man reflected in changes in cerebrospinal fluid concentration of sodium and calcium ions? Scand. J. clin. Lab. Invest.; 32: 309–310.
ROWELL, L. B. (1974): Human cardiovascular adjustments to exercise and thermal stress. Physiol. Rev., 54: 75–159.
ROWELL, L. B., BLACKMON, J. R., MARTIN, R. H., MAZZARELLA, J. A. and BRUCE, R. A. (1965): Hepatic clearance of indocyanine green in man under thermal and exercise stress. J. appl. Physiol., 20: 384–394.
SHIBOLET, M. S., FISHER, S., GILAT, T., BANK, H. and HETTER, R. H. (1962): Fibrinolysis and haemorrahages in fatal heat stroke. New Eng. J. Med., 266: 169–172.
SOBOCINSKA, J. and GREENLEAF, J. E. (1976): Cerebrospinal Fluid (Ca2+) and rectal temperature response during exercise in dogs. Amer. J. Physiol., 230: 1416–1419.
VARLEY, H. (1967): Practical Clinical Biochemistry 4 Ed. ELBS, William Heinemann Medical Books, London, 289, 413, 453, 485, pp.
WHAL, K. M., ABHAY KUMAR and PRAMOD NATH (1968): Biochemical changes in hyperthermia in albino rats, Ind. J. Med, Res., 56: 12–19.
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Deswal, K., Chohan, I.S. Effects of hyperthermia on enzymes and electrolytes in blood and cerebrospinal fluid in dogs. Int J Biometeorol 25, 227–233 (1981). https://doi.org/10.1007/BF02184523
- Blood Brain Barrier
- Heat Stress
- Chloride Concentration