Journal of Applied Phycology

, Volume 2, Issue 4, pp 305–308 | Cite as

Antimicrobial activities of polyether compounds of dinoflagellate origins

  • Hiroshi Nagai
  • Masayuki Satake
  • Takeshi Yasumoto


Twelve polyether compounds originating from dinoflagellates were tested for growth-inhibiting activities againstAspergillus niger, Penicillium funiculosum, Candida rugosa, Escherichia coli, Bacillus megaterium andStaphylococcus aureus by a paper disc method. These polyethers represent six groups of different skeletons and originate from three species;Prorocentrum lima, Dinophysis fortii andGambierdiscus toxicus. Potent antifungal activities were observed with okadaic acid and its two congeners, desulfated yessotoxin, and ciguatoxin but not with okadaic acid esters, prorocentrolide, pectenotoxin-1, yessotoxin, maitotoxin, and desulphated maitotoxin. The antifungal activities and mouse lethalities of the polyethers were markedly affected by slight modification of their structures. Antibacterial potency of the tested compounds was not significant.

Key words

polyether antimicrobial activity dinoflagellate antifungals chemical modification 


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Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • Hiroshi Nagai
    • 1
  • Masayuki Satake
    • 2
  • Takeshi Yasumoto
    • 2
  1. 1.Taiyo Central R&D Institute, Taiyo Fishery Co. LTD.TokyoJapan
  2. 2.Faculty of AgricultureTohoku UniversitySendaiJapan

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