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Pharmakologische Charakteriserung von synthetischem Hypertensin

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Summary

Synthetic hypertensin, RH II, a Val5octapeptide shows the same pattern of activity as natural hypertensin (angiotonin). In the normal rat, and in the rat pretreated with ganglionic blocking substances, the hypertensive activity corresponds to that of nor-adrenaline while it is enhanced in the nephrectomised animal. In the intact animal, hydralazine diminishes the hypertensive effect, while Regitin, Chlorpromazine and Reserpine are without effect. On the perfused vessels of the rabbit's hind limb, RH II produces a vasoconstriction which is diminished by Chlorpromazine and hydralazine, but not by Regitin. RH II is not destroyed by heating, but by freshly prepared kidney extract.

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Authors and Affiliations

  1. Pharmazeutische Abteilung, Aus den Forschungslaboratorien der CIBA A.G., Basel

    R. Meier, F. Gross, J. Tripod & H. Turrian

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  1. R. Meier
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  2. F. Gross
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  3. J. Tripod
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  4. H. Turrian
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Meier, R., Gross, F., Tripod, J. et al. Pharmakologische Charakteriserung von synthetischem Hypertensin. Experientia 13, 361–362 (1957). https://doi.org/10.1007/BF02179167

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