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Experientia

, Volume 16, Issue 5, pp 204–205 | Cite as

Die Wirkung des Hydrocortisons auf die infektionsbedingte lokale Leukozytenansammlung

  • R. Meier
  • B. Ecklin
Kurze Mitteilungen

Summary

The aggregation of leucocytes provoked in the peritoneal cavity of the white mouse by intraperitoneal injection of livingE. coli is inhibited by large doses of hydrocortisone. At the same time, the animal's susceptibility to infection is enhanced. The aggregation of leucocytes induced by injection of a bacterial extract containing lipopolysaccharides is inhibited in a similar manner. The effect of hydrocortisone sets in rapidly and subsides within 24 h. The inhibitory effect of hydrocortisone on the lipopolysaccharid effect on leucocytes seems to be an important factor in the influence of hydrocortisone on the infectious process.

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Copyright information

© Birkhäuser Verlag 1959

Authors and Affiliations

  • R. Meier
    • 1
  • B. Ecklin
    • 1
  1. 1.Pharmazeutische AbteilungForschungslaboratorien der CIBA AktiengesellschaftBasel

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