Summary
The influence of age on the comparative metabolism of lead and calcium was studied by application of radioactive markers (47Ca and203Pb) orally or intraperitoneally to female rats aged 4 weeks and 4 months. The body retention of both radioisotopes was determined over a period of 8 days. All retention values were higher in the younger group of animals. They were 3–4 times higher after oral and 1.3–1.7 times higher after intraperitoneal application of both markers. This indicates that the age related differences in metabolism are very similar for lead and calcium and that they are mostly due to changes in intestinal absorption.
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References
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Kostial, K., Kello, D. & Harrison, G.H. Comparative metabolism of lead and calcium in young and adult rats. Int. Arch. Arbeitsmed 31, 159–161 (1973). https://doi.org/10.1007/BF02178953
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DOI: https://doi.org/10.1007/BF02178953