Summary
18 hours after the injection of 0.2 mg colchicine a statistically significant increase in the activity of alkaline phosphatase in the rat-liver was observed.
The desintegration of desoxyribonucleic acid was not significantly increased.
Histochemic investigation of the alkaline phosphatase activity yielded corresponding results with a characteristic heightening of activity in the cell nuclei.
The relations between the inhibiting effect of colchicine on mitosis and the activation of alkaline phosphatase are discussed.
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Ebner, H., Strecker, H. Über die Wirkung des Colchicinsin vivo auf die alkalische Phosphatase der Rattenleber. Experientia 6, 388–389 (1950). https://doi.org/10.1007/BF02178940
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DOI: https://doi.org/10.1007/BF02178940