Summary
Whereas oxygen-free bases arise when an excess of LiAlH4 acts on lactames, the corresponding aminoaldehydes, which serve as points of departure for the possible synthesis of alkaloids by the cells, are obtained when calculated quantities of LiAlH4 are allowed to act on lactames. Through a corresponding reaction the not yet synthetically prepared 3-(α-Piperidyl)-propionaldehyde was formed from 2-oxooctahydroindolizine. Up to now the former has been assumed to be identical with the alkaloid of the pomegranate tree, pelletierine.
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References
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Galinovsky, F., Weiser, R. Über die Einwirkung von LiA1H4 auf Lactame. Experientia 6, 377–378 (1950). https://doi.org/10.1007/BF02178931
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DOI: https://doi.org/10.1007/BF02178931