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Journal of Radioanalytical and Nuclear Chemistry

, Volume 128, Issue 2, pp 85–92 | Cite as

Remote controlled unit for the production of [2-11C] isopropyl iodide

  • P. Goethals
  • J. Sambre
  • G. Slegers
  • D. Van Haver
Article

Abstract

A remote controlled system is described for the production of [2-11C] isopropyl iodide. The synthesis involves carbonation of methyl lithium with11CO2 followed by reduction with lithium aluminum hydride, hydrolysis and iodination with hydroiodic acid. The purification is performed by preparative gaschromatography on a Chromosorb 102-Porapak Q column. For a 30 min irradiation at 15 μA beam intensity the method yields about 300 mCi /11 GBq/ of radiochemically and chemically pure [2-11C] isopropyl iodide with a specific activity of 210 to 250 mCi. μmol−1 at the end of synthesis /EOB+25 min/. The remote controlled unit is also useful for the production of other alkyl iodides, acetone and acetic acid, labelled with11C.

Keywords

Hydrolysis Lithium Acetic Acid Gaschromatography Iodide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Akadémiai Kiadó 1988

Authors and Affiliations

  • P. Goethals
    • 1
  • J. Sambre
    • 1
  • G. Slegers
    • 1
  • D. Van Haver
    • 1
  1. 1.Laboratory of Analytical Chemistry, Institute for Nuclear SciencesRijksuniversiteit GentGentBelgium

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