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Isotope exchange of iodine between sodium iodide [Na131I] and [4-127I]iodoantipyrine via organic medium

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Abstract

The present investigation deals with a study of the isotope exchange reaction of iodine between sodium iodide [Na131I] and [4-127I]iodoantipyrine in organic medium, using different iodinating radioiodine reagents of different carrier-iodine concentration. A maximum saturation yield over 90% of pure [4-131I]iodoantipyrine has been obtained by performing the isotope exchange reaction in ethanol at 80°C in 30 min. The same yield has been obtained using the same concentrations by performing the reaction at room temperature (17–20°C) for 3 h. Also the rate of the isotope exchange reaction was found to be carrier-iodine dependent as well as time and temperature dependent. According to these results and reaction conditions, a kit form method was elaborated for the synthesis of [4-131I]iodoantipyrine as well as [4-123I]iodoantipyrine.

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Authors and Affiliations

  1. Radioisotope Production and Labelled Compounds Department, Nuclear Research Centre, Atomic Energy Authority, Cairo, Egypt

    G. El-Shaboury, K. Farah & S. El-Bayoumy

Authors
  1. G. El-Shaboury
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  2. K. Farah
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  3. S. El-Bayoumy
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El-Shaboury, G., Farah, K. & El-Bayoumy, S. Isotope exchange of iodine between sodium iodide [Na131I] and [4-127I]iodoantipyrine via organic medium. Journal of Radioanalytical and Nuclear Chemistry Letters 153, 201–209 (1991). https://doi.org/10.1007/BF02176875

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  • DOI: https://doi.org/10.1007/BF02176875

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