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Modulation of disseminated intravascular coagulation (DIC) by steroidal and non-steroidal anti-inflammatory drugs

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Abstract

Activation of the coagulation systems by endotoxin and release of vasoactive agents are both essential for the production of microthrombosis. Glucocorticoids prevent activation of factor XII by endotoxinin vivo and decrease production of tissue factor by macrophages. NSAID do not interfere with factor XII activation and increase the severity and risks of microthrombosis by inhibiting synthesis and release of protective prostaglandins. On the other hand, prolonged administration of glucocorticoids results in the reduction of the immune defence and fibrinolysis, increases the α-adrenergic response to endotoxin and sensitizes to endotoxin-induced intravascular coagulation like NSAID.

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Author notes

  1. Jean-Gilles Latour (Career Investigator)

    Present address: Conseil de la Recherche en Santé du Québec, Québec, Canada

Authors and Affiliations

  1. Laboratory of Experimental Pathology, Institut de Cardiologie de Montréal, 5000 East Bélanger street, H1T 1C8, Montréal, Québec, Canada

    Jean-Gilles Latour (Career Investigator)

  2. the Department of Pathology, Université de Montréal, Faculty of Medicine, 5000 East Bélanger street, H1T 1C8, Montréal, Québec, Canada

    Jean-Gilles Latour (Career Investigator)

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  1. Jean-Gilles Latour
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Additional information

Supported by Grant MT-4478 of the Medical Research Council; presented at the ‘Fourth European Workshop on Inflammation’, Antwerp, Belgium, March 1982.

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Latour, JG. Modulation of disseminated intravascular coagulation (DIC) by steroidal and non-steroidal anti-inflammatory drugs. Agents and Actions 13, 487–495 (1983). https://doi.org/10.1007/BF02176420

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