The effect of dapsone on complement activation

Summary

Thus we have determined that dapsone, under a variety of conditions, failed to inhibit eitherin vitro orex vivo — both classical and alternative pathway complement activation. Other mechanisms must explain dapsone's therapeutic effect on inflammation, both in man and in animals. The failure to detect anti-complement effects of suramin and sodium aurothiomalateex vivo shed doubt on the relevance of anti-complement activity identifiedin vitro.