Advertisement

Experientia

, Volume 8, Issue 10, pp 379–380 | Cite as

The presence of 5-hydroxytryptamine in the venom ofBufo marinus

  • S. Udenfriend
  • C. T. Clark
  • E. Titus
Kurze Mitteilungen

Keywords

Enteramin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Zusammenfassung

5-Hydroxytryptamin (Serotonin, Enteramin, Thrombocytin), das in neuerer Zeit aus Blut oder Gewebe verschiedener Tiere isoliert wurde, konnte nun auch unter Verwendung von Isotopentechnik und Papierchromatographie als unmethylierter Vorläufer der schon bekannten Krötenbasen im Giftextrakt vonBufo marinus im Ausmasse von 0,1 % (bezogen auf trockenen Giftextrakt) nachgewiesen werden.

References

  1. 1.
    M. M. Rapport, A. A. Green, andI. H. Page, J. Biol. Chem.176, 1243 (1948).Google Scholar
  2. 2.
    M. Rand andG. Reid, Nature168, 385 (1951).Google Scholar
  3. 3.
    V. Erspamer andA. Ottolenghi, Exper.8, 31 (1952).Google Scholar
  4. 4.
    H. Jensen andK. K. Chen, J. Biol. Chem.116, 87 (1936).Google Scholar
  5. 5.
    H. Wieland, Ann. Chem.513, 1 (1934).Google Scholar
  6. 1.
    We wish to thank Dr.C. Bernard Lewis of the Institute of Jamaica for supplying the specimens ofBufo marinus.Google Scholar
  7. 2.
    L. C. Craig, J. Biol. Chem.155, 519 (1944).Google Scholar
  8. 3.
    5-Hydroxytryptamine, as the creatinine sulfate complex, was generously supplied by the Abbott Laboratories, North Chicago, Illinois, U.S.A.Google Scholar
  9. 2.
    The radioactivity of the samples, which were essentially weightless, was measured with a 1.8 mg/cm2 mica window G. M. counter. The amounts of I131 and S35 in each sample were determined by measurement of radioactivity with and without an aluminum absorber as described byA. S. Keston, S. Udenfriend andM. Levy, J. Amer. Chem. Soc.72, 748 (1950) andS. Udenfriend, J. Biol. Chem.187, 65 (1950).Google Scholar

Copyright information

© Birkhäuser Verlag 1952

Authors and Affiliations

  • S. Udenfriend
    • 1
  • C. T. Clark
    • 1
  • E. Titus
    • 1
  1. 1.Section on Chemical PharmacologyNational Heart Institute, National Institutes of Health, Public Health Service, Federal Security AgencyBethesda

Personalised recommendations