Abstract
When applied as 0.1% or 0.5% eye drops 9 times a day at hourly intervals, BVDU [(E)-5-(2-bromovinyl)-2′-deoxy-uridine] did not retard the regeneration of rabbit corneal epithelium. Nor did it exert any toxic effects on the cells. Likewise, IDU (5-iodo-2′-deoxyuridine) 0.1% eye drops did not significantly reduce the rate of epithelium wound closure. However, IDU produced toxic alterations in the cells.
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Maudgal, P.C., De Kimpe, N., De Clercq, E. et al. Influence of (E)-5-(2-Bromovinyl)-2′-deoxyuridine on corneal epithelium healing. Graefe's Arch Clin Exp Ophthalmol 218, 275–281 (1982). https://doi.org/10.1007/BF02175897
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DOI: https://doi.org/10.1007/BF02175897