Summary
Gross and microscopial morphological changes developing in female guinea-pigs after vaginal infection with HVH 2/Angelotti were studied. In the mucosa of the external genital tract there were inflammatory changes with formation of intra-epithelial vesicles, erosions and ulcerations. In the late stages of the infection signs of inflammatory dysplasia were also observed. The infection spread into the nervous system and produced characteristic inflammatory changes. The inflammation began as a bilateral posterior myelitis and ascended in the course of infection through the upper spinal-cord towards the brain-stem. The morphological changes were preceded by increased virus replication in the respective tissues and were correlated in time with clinical symptoms. The morphological changes seen at the site of inoculation in the external genital tract of the guinea-pig bore a certain resemblance to those seen in some cases of human infection with the same type of virus.
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References
Baringer, J. R.: Herpes simplex virus in human sacral ganglion. New England J. Med.291/16, 828–829 (1974).
Blackwood, W., McMenemey, W. H., Meyer, A., Norman, R. M., Rusel, D. S.: In: Greenfield's Neuropathology, 205–206. London: Ed. Arnold Publ., 1963.
Cook, M. L., Stevens, J. G.: Pathogenesis of herpetic neuritis and ganglionitis in mice: evidence for intraaxonal transport of infection. Infect. Immun.7, 272–288 (1973).
Doerr, R., Hallauer, C.: Die primäre Herpesmyelitis und ihre Beziehungen zum Infektionsmodus sowie zur Wirtspezies. Zeitschr. Hyg. Infektskrankh. (Berlin)118/4, 474–506 (1936).
Doerr, R., Hallauer, C.: Handbuch der Virusforschung, 726. Wien: Julius Springer, 1939.
Editorial: Herpes genitalis. Brit. med. J.5759, 264–265 (1972).
Field, I. E.: Pathogenesis of herpetic encephalitis following corneal and masseteric inoculation. J. Path. Bact.4, 1–11 (1952).
Goodpasture, E. W., Teague, O.: Transmission of the virus of herpes febrilis along nerves in experimentally infected rabbits. J. Med. Res.44, 139–184 (1923).
Goodpasture, E. W.: The axis cylinders of peripheral nerves as portals of entry to the central nervous system for the virus of herpes simplex in experimentally infected rabbits. Amer. J. Pathol.1, 11–28 (1925).
Habermann, R. T., Williams, F. P., Fite, G. L.: Inclusion bodies associated with viral diseases. J. Amer. Vet. Med. Ass.137, 161–176 (1960).
Haller, F. R., Haller, A. C.: The fine structure of cellular layers and connective tissue space at spinal nerve root attachements in the rat. Amer. J. Anat.133, 109–123 (1972).
Hill, T. J., Field, H. J., Roome, A. P. C.: Intra-axonal location of herpes simplex virus particles. J. gen. Virol.15, 253–255 (1972).
Johnson, R. T.: The pathogenesis of herpes virus encephalitis. I. Virus pathways to the nervous system of suckling mice demonstrated by fluorescent antibody staining. J. exp. Med.119, 343–356 (1964).
Kristensson, K., Lycke, E., Sjöstrand, J.: Transport of herpes simplex virus in peripheral nerves. Acta Physiol. Scand. Suppl.357, 13–14 (1971).
Kristensson, K., Olson, Y.: Retrograde axonal transport of protein. Brain Res.29, 363–365 (1971).
Kristensson, K., Lycke, E., Sjöstrand, J.: Spread of herpes virus simplex in peripheral nerves. Acta Neuropath. (Berlin)17, 44–53 (1971).
Lukáš, B., Wiesendanger, W., Schmidt-Ruppin, K. H.: Genital herpes in guinea pigs. Arch. ges. Virusforsch.44, 153–155 (1974).
Lukáš, B., Wiesendanger, W., Schmidt-Ruppin, K. H.: Herpes genitalis in guinea pigs. I. Kinetic study in infection with Herpesvirus hominis Type 2. Arch. Virol.48, 319–329 (1975).
Moffat, R. E., Schiefer, B.: Microsporidiosis (encephalitozoonosis) in the guinea-pig. Laboratory Animal Science23/2, 282–284 (1973).
Nahmias, A. J., London, W. T., Catalano, L. W., Fuccillo, D. A., Sever, J. C., Graham, C.: Genital herpesvirus hominis Typ 2 infection: An experimental model in Cebus monkeys. Science171, 297–298 (1971).
Nasemann, T.: Die Histologie der Viruskrankheiten der Haut. In: Spezielle pathologische Anatomie, Bd. 7, 35–40. Berlin-Heidelberg-New York: Springer, 1973.
Novak, E. R., Woodruff, J. D.: Gynecologic and obstetric pathology. Philadelphia-London: W. B. Saunders, 1967.
Paine, T. F.: Latent herpes simplex infections in man. Bact. Rev.28, 472–479 (1964).
Pette, H.: Herpesenzephalomyelitis. In: Handbuch der speziellen pathologischen Anatomie und Histologie, Bd.XIII a, 494–510. Berlin-Göttingen-Heidelberg: Springer, 1958.
Pinkerton, H.: The morphology of viral inclusions and their practical importance in the diagnosis of human disease. Amer. J. clin. Pathol.20, 201–207 (1950).
Rabin, E. R., Jenson, A. B., Melnick, J. L.: Herpes simplex virus in mice: electron microscopy of neural spread. Science162, 126–127 (1968).
Rajcani, J., Scott, B. S.: Growth of herpes simples virux in cultures of dissociated human nervous tissue. Acta virol.16, 25–30 (1972).
Rajcani, J., Conen, P. E.: Observations on neural spread of herpes simplex virus in suckling mice. An electron microscopic study. Acta virol.16, 31–40 (1972).
Rose, G., Walthard, B.: Versuche über Herpesinfektion und Herpesimmunität beim Meerschweinchen. Zeitschr. Hyg. Infektskrankh. (Berlin)105, 3/4, 645–676 (1926).
Stevens, J. G., Cook, M. L.: Latent herpes simplex virus in spinal ganglia of mice. Science173, 843–845 (1971).
Wildy, P.: The progression of herpes simplex virus to the central nervous system of the mouse. J. Hyg.65, 173–192 (1967).
Wright, G. P.: Nerve trunks as pathways in infection. Proc. Roy. Soc. Med.46, 319–330 (1953).
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Krinke, G., Žák, F., Lukáš, B. et al. Herpes genitalis in guinea-pigs. Archives of Virology 49, 13–24 (1975). https://doi.org/10.1007/BF02175591
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DOI: https://doi.org/10.1007/BF02175591