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Antagonism between tropolone and colchicine in rat fibroblast cultures

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Résumé

Il a été démontré ici que la tropolone, analogue simple de la colchicine, est capable d'agir comme antagoniste puissant de celle-ci. Dans une culture de fibroblastes du rat soumise à l'action d'un mélange de ces deux agents, cette action — consistant dans la disparition soudaine de l'arrêt métaphasique produit par la colchicine—commence à se manifester après 16 h.

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References

  1. M. R. Murray, H. H. de Lam (Benitez), andE. Chargaff, Exper. Cell. Res.2, 165 (1951).

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  2. We are indebted to Prof. W. v.E. Doering, Yale University, for this substance.

  3. H. Benitez, M. R. Murray, andE. Chargaff, Anat. Rec.112, 309 (1952).

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  4. M. R. Murray, H. H. de Lam (Benitez), andE. Chargaff, Exper. Cell. Res.2, 165 (1951).

    Article  CAS  Google Scholar 

  5. M. R. Murray, H. H. de Lam (Benitez), andE. Chargaff, Exper. Cell. Res.2, 165 (1951).

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Authors and Affiliations

  1. Department of Surgery, Anatomy, and Biochemistry, College of Physicians and Surgeons, Columbia University, New York 32, N.Y.

    Helena H. Benitez, Margaret R. Murray & E. Chargaff

Authors
  1. Helena H. Benitez
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  2. Margaret R. Murray
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  3. E. Chargaff
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Benitez, H.H., Murray, M.R. & Chargaff, E. Antagonism between tropolone and colchicine in rat fibroblast cultures. Experientia 9, 426–427 (1953). https://doi.org/10.1007/BF02175532

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  • DOI: https://doi.org/10.1007/BF02175532

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