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Diabetogene Wirkung des 2,3,4-Triketo-Tetrahydropyridins

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Summary

It is shown that 2,3,4-triketo-tetrahydropyridine (I) exercises a diabetogenic activity on white rats when given in a dose of 80 mg/kg body weight. It is suggested that the group -COCOCONH- is responsible for this activity. This is in accordance with the observation that monoalkyl derivatives of alloxane show diabetogenic activity, while dialkyl derivatives show none.

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References

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Authors and Affiliations

  1. Chemisches Institut und Physiologisches Institut der Universität Zagreb, Jugoslawien

    N. Allegretti, K. Balenovič, V. Fišter & R. Munk

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  1. N. Allegretti
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  2. K. Balenovič
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  3. V. Fišter
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  4. R. Munk
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Allegretti, N., Balenovič, K., Fišter, V. et al. Diabetogene Wirkung des 2,3,4-Triketo-Tetrahydropyridins. Experientia 9, 416–417 (1953). https://doi.org/10.1007/BF02175524

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  • DOI: https://doi.org/10.1007/BF02175524

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