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Experientia

, Volume 9, Issue 11, pp 405–412 | Cite as

Die Wirkung synaptotroper Substanzen auf gewisse efferente und afferente Strukturen des autonomen Nervensystems

  • H. Konzett
  • E. Rothlin
Article

Summary

Synaptotropic substances, i.e. substances acting on autonomic ganglia, may also have an action on the suprarenal medulla which is an efferent organ of the sympathetic nervous system and can be regarded as a modified sympathetic ganglion. Moreover, synaptotropic substances exert effects on certain afferent structures bearing a close anatomical and functional relationship to the autonomic nervous system, e.g. the chemoreceptor system in the carotid body and the cardiac receptors responsible for theBezold-Jarisch effect. As a rule, synaptotropic excitatory substances stimulate the suprarenal medulla (secretion of hormone) and the other afferent structures referred to, while synaptotropic inhibitory substances exert a depressive action. There are, however, exceptions to this rule.

It seems especially remarkable that synaptotropic substances are also able to exert effects on afferent structures in which there are no synapses. The presence of a morphologically distinct synapse is not, therefore, a necessary condition for their action.

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Copyright information

© Verlag Birkhäuser 1953

Authors and Affiliations

  • H. Konzett
    • 1
  • E. Rothlin
    • 1
  1. 1.Pharmakologisches Laboratorium der Sandoz AG.Basel

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