Cysteine proteinases in arthritis and inflammation

Summary

Balanced enzymatic activity is one of the keystones of physiology and pathophysiology. In organisms, the up- and downregulation of proteolytic enzymes reflects physiological adaptation as well as the presence or development of disease. Advances in molecular biology have revealed numerous aspects in the field of cysteine proteinase research. Several novel members of this growing family of proteinases, such as cathepsins H, S, and O, have been found to participate in inflammatory and arthritic diseases. Interestingly, the majority of the data addressing the involvement of cysteine proteinases in pathophysiological pathways are the result of intensive research on two diseases, periodontal disease and rheumatoid arthritis, which share distinct features of cysteine-proteinase-modulated inflammation and matrix degradation.

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Müller-Ladner, U., Gay, R.E. & Gay, S. Cysteine proteinases in arthritis and inflammation. Perspectives in Drug Discovery and Design 6, 87–98 (1996). https://doi.org/10.1007/BF02174047

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Keywords

  • Polymer
  • Rheumatoid Arthritis
  • Arthritis
  • Enzymatic Activity
  • Cysteine