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Perspectives in Drug Discovery and Design

, Volume 6, Issue 1, pp 87–98 | Cite as

Cysteine proteinases in arthritis and inflammation

  • Ulf Müller-Ladner
  • Renate E. Gay
  • Steffen Gay
Article

Summary

Balanced enzymatic activity is one of the keystones of physiology and pathophysiology. In organisms, the up- and downregulation of proteolytic enzymes reflects physiological adaptation as well as the presence or development of disease. Advances in molecular biology have revealed numerous aspects in the field of cysteine proteinase research. Several novel members of this growing family of proteinases, such as cathepsins H, S, and O, have been found to participate in inflammatory and arthritic diseases. Interestingly, the majority of the data addressing the involvement of cysteine proteinases in pathophysiological pathways are the result of intensive research on two diseases, periodontal disease and rheumatoid arthritis, which share distinct features of cysteine-proteinase-modulated inflammation and matrix degradation.

Keywords

Polymer Rheumatoid Arthritis Arthritis Enzymatic Activity Cysteine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© ESCOM Science Publishers B.V 1996

Authors and Affiliations

  • Ulf Müller-Ladner
    • 1
    • 2
  • Renate E. Gay
    • 1
    • 2
  • Steffen Gay
    • 1
    • 2
  1. 1.Division of Clinical Immunology and Rheumatology, Department of MedicineUniversity of Alabama at BirminghamBirminghamU.S.A.
  2. 2.Center for Experimental RheumatologyUniversity HospitalZürichSwitzerland

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