Skip to main content
SpringerLink
Log in

Cysteine proteinases in arthritis and inflammation

  • Published:
Perspectives in Drug Discovery and Design

Summary

Balanced enzymatic activity is one of the keystones of physiology and pathophysiology. In organisms, the up- and downregulation of proteolytic enzymes reflects physiological adaptation as well as the presence or development of disease. Advances in molecular biology have revealed numerous aspects in the field of cysteine proteinase research. Several novel members of this growing family of proteinases, such as cathepsins H, S, and O, have been found to participate in inflammatory and arthritic diseases. Interestingly, the majority of the data addressing the involvement of cysteine proteinases in pathophysiological pathways are the result of intensive research on two diseases, periodontal disease and rheumatoid arthritis, which share distinct features of cysteine-proteinase-modulated inflammation and matrix degradation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Cazzulo, J.J. and Frasch, A.C., FASEB J., 6 (1992) 3259.

    Google Scholar 

  2. Lemere, C.A., Munger, J.S., Shi, G.-P., Natkin, L., Haass, C., Chapman, H.A. and Selkoe, D.J., Am. J. Pathol., 146 (1995) 848.

    Google Scholar 

  3. Saito, K., Elce, J.S., Hamos, J.E. and Nixon, R.A., Proc. Natl. Acad. Sci. USA, 90 (1993) 2628.

    Google Scholar 

  4. Shi, G.-P., Webb, A., Foster, K., Knoll, J., Lemere, C., Munger, J. and Chapman, H., J. Biol. Chem., 269 (1994) 11530.

    Google Scholar 

  5. Barrett, A. and Kirschke, H., Methods Enzymol., 80 (1981) 535.

    Google Scholar 

  6. Sloane, B.F., Moin, K., Krepala, E. and Rozhin, J., Cancer Metastasis Rev., 9 (1990) 333.

    Google Scholar 

  7. Sloane, B.F., Rozhin, J., Krepela, E., Zeigler, G. and Sameni, M., Biomed. Biochim. Acta, 50 (1991) 549.

    Google Scholar 

  8. Duffy, M.J., Clin. Exp. Metastasis, 10 (1992) 145.

    Google Scholar 

  9. Luthgens, K., Ebert, W., Trefz, G., Gabrijelcic, D., Turk, V. and Lah, T.T., Cancer Detect. Prev., 17 (1993) 387.

    Google Scholar 

  10. Velasco, G., Ferrando, A.A., Puente, X.S., Sánchez, L.M. and López-Otín, C., J. Biol. Chem., 43 (1994) 27136.

    Google Scholar 

  11. Howie, A.J., Burnett, D. and Crocker, J., J. Pathol., 145 (1985) 307.

    Google Scholar 

  12. Brömme, D. and Okamoto, K., Biol. Chem. Hoppe-Seyler, 376 (1995) 379.

    Google Scholar 

  13. Mohr, W., Akt. Rheumatol., 13 (1988) 5.

    Google Scholar 

  14. Gay, S., Gay, R.E. and Koopman, W.J., Ann. Rheum. Dis., 52 (1993) S39.

    Google Scholar 

  15. Lah, T.T., Skaleric, U., Babnik, J. and Turk, V., J. Periodont. Res., 20 (1985) 458.

    Google Scholar 

  16. Lah, T.T., Skaleric, U., Babnik, J. and Turk, V., J. Periodont. Res., 21 (1986) 504.

    Google Scholar 

  17. Williams, R.C., New Engl. J. Med., 322 (1990) 373.

    Google Scholar 

  18. Gay, S. and Gay, R.E., Rheumatol. Int., 9 (1989) 105.

    Google Scholar 

  19. Müller-Ladner, U., Curr. Opin. Rheumatol., 7 (1995) 222.

    Google Scholar 

  20. Bishop, J.M., Cell, 64 (1991) 235.

    Google Scholar 

  21. Tsujimoto, A., Nyunoya, H., Morita, T., Sato, T. and Shimotohno, K., J. Virol., 65 (1991) 1420.

    Google Scholar 

  22. Joseph, L., Lapid, S. and Sukhatme, V.P., Nucleic Acids Res., 15 (1987) 3186.

    Google Scholar 

  23. Mason, R.W., Wilcox, D., Wikstrom, P. and Shaw, E.N., Biochem. J., 257 (1989) 125.

    Google Scholar 

  24. Denhardt, D.T., Greenberg, A.H., Egan, S.E., Hamilton, R.T. and Wright, J.A., Oncogene, 2 (1987) 55.

    Google Scholar 

  25. Trabandt, A., Aicher, W.K., Gay, R.E., Sukhatme, V.P., Fassbender, H.-G., Nilson-Hamilton, M., Hamilton, R.T., McGhee, J.R. and Gay, S., Matrix, 10 (1991) 349.

    Google Scholar 

  26. Müller-Ladner, U., Kriegsmann, J., Gay, R.E. and Gay, S., Rheum. Dis. Clin. N. Am., 21 (1995) 675.

    Google Scholar 

  27. Katunuma, N., Adv. Enzyme Regul., 30 (1990) 377.

    Google Scholar 

  28. Achkar, C., Gong, O., Frankfater, A. and Bajkowski, A.S., J. Biol. Chem., 265 (1990) 13650.

    Google Scholar 

  29. Trabandt, A., Aicher, W.K., Gay, R.E., Sukhatme, V.P., Fassbender, H.G. and Gay, S., Rheumatol. Int., 12 (1992) 53.

    Google Scholar 

  30. Reddy, V.Y., Zhang, Q.-Y. and Weiss, S.J., Proc. Natl. Acad. Sci. USA, 92 (1995) 3849.

    Google Scholar 

  31. Ripple, R.E., Lohr, K.M., Twining, S.S., Hyndiuk, R.A. and Caya, J.G., Invest. Ophthalmol. Vis. Sci., 27 (1986) 926.

    Google Scholar 

  32. Buttle, D.J., Burnett, D. and Abrahamson, M., Scand. J. Clin. Lab. Invest., 50 (1990) 509.

    Google Scholar 

  33. Schmidt, M., Heinrich, J. and Pfeifer, M., Pneumologie, 44 (Suppl. 1) (1990) 308.

    Google Scholar 

  34. Kreutzberg, G.W., Arzneim.-Forsch. Drug Res., 45 (1995) 357.

    Google Scholar 

  35. Kunimatsu, M., Higashiyama, S., Sato, K., Ohkubo, I. and Sasaki, M., Biochem. Biophys. Res. Commun., 164 (1989) 875.

    Google Scholar 

  36. Rollag, H. and Morland, B., Scand. J. Rheumatol., 76 (1988) 79.

    Google Scholar 

  37. Verbanac, D., Zanetti, M. and Romeo, D., FEBS Lett., 317 (1993) 255.

    Google Scholar 

  38. Burnett, D. and Stockley, R.A., Clin. Sci., 68 (1985) 469.

    Google Scholar 

  39. Lesser, M., Chang, J.C. and Orlowski, M., Mol. Cell. Biol., 69 (1985) 67.

    Google Scholar 

  40. Shi, G.-P., Munger, J., Meara, J., Rich, D. and Chapman, H.A., J. Biol. Chem., 267 (1992) 7258.

    Google Scholar 

  41. Matsunaga, Y., Saibara, T., Kido, H. and Katunuma, N., FEBS Lett., 324 (1993) 325.

    Google Scholar 

  42. Mizuochi, T., Yee, S.T., Kasai, M., Kakiuchi, T., Muno, D. and Kominami, E., Immunol. Lett., 43 (1994) 189.

    Google Scholar 

  43. Reyes, V.E., Lu, S. and Humphreys, R.E., J. Immunol., 146 (1991) 3877.

    Google Scholar 

  44. Gordon, R.D., Young, D.A., Rayner, S., Luke, R.W., Crowther, M.L., Wordsworth, P., Bell, J., Hassall, G., Evans, J., Hinchcliffe, S.A., Culbert, E.J. and Davison, M.D., Eur. J. Immunol., 25 (1995) 1473.

    Google Scholar 

  45. Kalden, J.R. and Gay, S., Clin. Exp. Immunol., 98 (1994) 1.

    Google Scholar 

  46. Stransky, G., Moreland, L.W., Gay, R.E. and Gay, S., Br. J. Rheumatol., 32 (1993) 1044.

    Google Scholar 

  47. Roberts, C.R., Herrmann, M., Aicher, W.K., Müller-Ladner, U., Matsumoto, S., Gay, R.E., Kalden, J.R. and Gay, S., Arthritis Rheum., 38 (1995) S218.

  48. Jochum, M., Gippner-Steppert, C., Machleidt, W. and Fritz, H., Am. J. Resp. Crit. Care Med., 150 (1994) S123.

  49. Assfalg-Machleidt, I., Jochum, M., Nast-Kolb, D., Siebeck, M., Billing, A., Joka, T., Rothe, G., Valet, G., Zauner, R. and Scheuber, H.P., Biol. Chem. Hoppe-Seyler, 371 (1990) 211.

    Google Scholar 

  50. Potempa, J., Dubin, A., Korzus, G. and Travis, J., J. Biol. Chem., 263 (1988) 2664.

    Google Scholar 

  51. Sakakura, K., Hamaguchi, Y., Harada, T., Yamagiwa, M. and Sakakura, Y., Ann. Otol. Rhinol. Laryngol., 99 (1990) 379.

    Google Scholar 

  52. Hamaguchi, Y., Ohi, M., Sakakura, Y. and Miyoshi, Y., Rhinology, 24 (1986) 187.

    Google Scholar 

  53. Hamaguchi, Y., Taya, M., Suzumura, H. and Sakakura, Y., Am. J. Otolaryngol., 11 (1990) 37.

    Google Scholar 

  54. Shikimi, T., Yamamoto, D. and Handa, M., J. Pharmacobio-Dynam., 10 (1987) 750.

    Google Scholar 

  55. Steer, M.L., Arch. Surg., 127 (1992) 1350.

    Google Scholar 

  56. Baricos, W.H., Cortez, S.L., Le, Q.C., Wu, L.-T., Shaw, E., Hanada, K. and Shaw, S.V., Arch. Biochem. Biophys., 288 (1991) 468.

    Google Scholar 

  57. Thomas, G.J. and Davies, M., Biochem. Biophys. Acta, 990 (1989) 246.

    Google Scholar 

  58. Smalley, J.W., Birss, A.J., Kay, H.M., McKee, A.S. and Marsh, P.D., Oral Microbiol. Immunol., 4 (1989) 178.

    Google Scholar 

  59. Chen, Z., Potempa, J., Polanowski, A., Wikstrom, M. and Travis, J., J. Biol. Chem., 267 (1992) 18896.

    Google Scholar 

  60. Lah, T.T., Babnik, J., Schiffmann, E., Turk, V. and Skaleric, U., J. Periodontol., 64 (Suppl. 5) (1993) 485.

    Google Scholar 

  61. Eley, B.M. and Cox, S.W., J. Clin. Periodontol., 18 (1991) 499.

    Google Scholar 

  62. Eley, B.M., Cox, S.W. and Watson, R.M., Clin. Oral Impl. Res., 2 (1991) 62.

    Google Scholar 

  63. Eley, B.M. and Cox, S.W., J. Periodont. Res., 27 (1992) 62.

    Google Scholar 

  64. Kennett, C.N., Cox, S.W. and Eley, B.M., J. Periodont. Res., 29 (1994) 203.

    Google Scholar 

  65. Eeckhout, Y. and Vaes, G., Biochem. J., 166 (1977) 21.

    Google Scholar 

  66. Trabandt, A., Müller-Ladner, U., Kriegsmann, J., Gay, R.E. and Gay, S., Lab. Invest., 73 (1995) 205.

    Google Scholar 

  67. Jonsson, R., Pitts, A., Lue, C., Gay, S. and Mestecky, J., J. Clin. Periodontol., 18 (1991) 703.

    Google Scholar 

  68. Huet, G., Flipo, R.M., Richet, C., Thiebaut, C., Demeyer, D., Balduyck, M., Duquesnoy, B. and Degand, B., Clin. Chem., 38 (1992) 1694.

    Google Scholar 

  69. Lenarcic, B., Gabrijelcic, D., Rozman, B., Drobnic-Kosorok, M. and Turk, V., Biol. Chem. Hoppe-Seyler, 369 (1988) 257.

    Google Scholar 

  70. Flipo, R.M., Heron, F., Huet, G., Balduyck, M., Degand, P., Duquesnoy, B. and Delcambre, B., Rev. Rhum. Malad. Osteo-Articul., 58 (1991) 131.

    Google Scholar 

  71. Gabrijelcic, D., Annan-Prah, A., Rodic, B., Rozman, B., Cotic, V. and Turk, V., J. Clin. Chem. Clin. Biochem., 28 (1990) 149.

    Google Scholar 

  72. O'Sullivan, F.X., Fassbender, H.G., Gay, S. and Koopman, W.J., Arthritis Rheum., 28 (1985) 529.

    Google Scholar 

  73. Meijers, H.M., Koopdonk-Kool, J., Meacock, S.C.R., Van Noorden, C.J.F., Bunning, R.A. and Billingham, M.E.J., Agents Actions Suppl., 39 (1993) C219.

  74. Etherington, D.J., Taylor, M.A. and Henderson, B., Br. J. Exp. Pathol., 69 (1988) 281.

    Google Scholar 

  75. Van Noorden, C.J.F., Smith, R.E. and Rasnick, D., J. Rheumatol., 15 (1988) 1525.

    Google Scholar 

  76. Codorean, E. and Gabrielescu, E., Morphol. Embryol., 31 (1985) 269.

    Google Scholar 

  77. Watanabe-Fukunaga, R., Brannan, C.I., Copeland, N.G., Jenkins, N.A. and Nagata, S., Nature, 356 (1992) 314.

    Google Scholar 

  78. Fassbender, H.G., Coll. Relat. Res., 3 (1983) 141.

    Google Scholar 

  79. Gay, S., Müller-Ladner, U. and Gay, R.E., Diabetes Res. Clin. Pract., 30 (1996) S131.

    Google Scholar 

  80. Trabandt, A., Gay, R.E., Fassbender, H.G. and Gay, S., Arthritis Rheum., 34 (1991) 1444.

    Google Scholar 

  81. Brinckerhoff, C.E. and Harris, E.D., Am. J. Pathol., 103 (1981) 411.

    Google Scholar 

  82. Adams, C.D., Zhou, T. and Mountz, J.D., Arthritis Rheum., 33 (1990) S120.

  83. Rendt, K.E., Barry, T.S., Jones, D.M., Richter, C.B., McCachren, S.S. and Haynes, B.F., J. Immunol., 151 (1993) 7324.

    Google Scholar 

  84. Geiler, T., Kriegsmann, J., Keyszer, G., Gay, R.E. and Gay, S., Arthritis Rheum., 37 (1994) 1664.

    Google Scholar 

  85. Müller-Ladner, U., Kriegsmann, J., Franklin, B., Matsumoto, S., Gay, R.E. and Gay, S., Am. J. Pathol., (1996) in press.

  86. Nguyen, Q., Mort, J.S. and Roughley, P.J., Biochem. J., 266 (1990) 569.

    Google Scholar 

  87. Krane, S.M., Conca, W., Stephenson, M.L., Amento, E.P. and Goldring, M.B., Ann. New York Acad. Sci., 580 (1990) 350.

    Google Scholar 

  88. Vincenti, M.P., Clark, I.M. and Brinckerhoff, C.E., Arthritis Rheum., 37 (1994) 1115.

    Google Scholar 

  89. Maciewicz, R.A. and Wotton, S.F., Biomed. Biochem. Acta, 50 (1991) 561.

    Google Scholar 

  90. Guinec, N., Dalet-Fumeron, V. and Pagano, M., Biol. Chem. Hoppe-Seyler, 374 (1993) 1135.

    Google Scholar 

  91. Ziff, M., Rheumatol. Int., 9 (1989) 97.

    Google Scholar 

  92. Keyszer, G.M., Heer, A.H., Kriegsmann, J., Geiler, T., Trabandt, A., Keysser, M., Gay, R.E. and Gay, S., Arthritis Rheum., 38 (1995) 976.

    Google Scholar 

  93. Krieger, N.S., Sukhatme, V.P. and Bushinsky, D.A., J. Bone Miner. Res., 5 (1990) 159.

    Google Scholar 

  94. Buttle, D.J., Saklatvala, J. and Barret, A.J., Agents Actions Suppl., 39 (1993) 161.

    Google Scholar 

  95. Maciewicz, R.A., Wotton, S.F., Etherington, D.J. and Duance, V.C., FEBS Lett., 269 (1990) 189.

    Google Scholar 

  96. Tanuguchi, S., Nishimura, Y., Takahashi, T., Baba, T. and Kato, K., Biochem. Biophys. Res. Commun., 168 (1990) 520.

    Google Scholar 

  97. Pagano, M., Capony, F. and Rochefort, H., CR Acad. Sci., 309 (1989) 7.

    Google Scholar 

  98. Dalet-Fumeron, V., Guinec, N. and Pagano, M., FEBS Lett., 332 (1993) 251.

    Google Scholar 

  99. Buttle, D.J., Handley, C.J., Ilic, M.Z., Saklatvala, J., Murata, M. and Barrett, A.J., Arthritis Rheum., 36 (1993) 1709.

    Google Scholar 

  100. Esser, R.E., Watts, L.M., Angelo, R.A., Thornburg, L.P., Prior, J.J. and Palmer, J.T., J. Rheumatol., 20 (1993) 1176.

    Google Scholar 

  101. Huet, G., Flipo, R.M., Colin, C., Janin, A., Hemon, B., Collyn-d'Hooghe, M., Lafyatis, R., Duquesnoy, B. and Degand, P., Arthritis Rheum., 36 (1993) 772.

    Google Scholar 

  102. Fujimori, Y., Shimizu, K., Suzuki, K., Nagakawa, Y., Yamamoto, S. and Yamamuro, T., Z. Rheumatol., 53 (1994) 72.

    Google Scholar 

  103. Szomor, Z., Shimizu, K., Fujimori, Y., Yamamoto, S. and Yamamuro, T., Ann. Rheum. Dis., 54 (1993) 477.

    Google Scholar 

  104. Fukui, I., Tanaka, K. and Murachi, T., Biochem. Biophys. Res. Commun., 162 (1989) 559.

    Google Scholar 

  105. Yamamoto, S., Shimizu, K., Suzuki, K., Nagakawa, Y. and Yamamuro, T., Arthritis Rheum., 35 (1992) 1309.

    Google Scholar 

  106. Despres, N., Talbot, G., Plouffe, B., Boire, G. and Menard, H.A., J. Clin. Invest., 95 (1995) 1891.

    Google Scholar 

  107. Mimori, T., Suganuma, K., Tanami, Y., Nojima, T., Matsumura, M., Fujii, Y., Suzuki, K. and Akizuki, M., Proc. Natl. Acad. Sci. USA, 92 (1995) 7267.

    Google Scholar 

  108. Pelletier, J.P., Faure, M.P., DiBattista, J.A., Wilhelm, S., Visco, D. and Martel-Pelletier, J., Am. J. Pathol., 142 (1991) 95.

    Google Scholar 

  109. Baici, A. and Lang, A., Cell Tissue Res., 259 (1990) 567.

    Google Scholar 

  110. Baici, A., Horler, D., Lang, A., Merlin, C. and Kissling, R., Ann. Rheum. Dis., 54 (1995) 281.

    Google Scholar 

  111. Müller-Ladner, U., Kriegsmann, J., Gay, R.E., Koopman, W.J., Gay, S. and Chatham, W.W., Arthritis Rheum., 38 (1995) 1328.

    Google Scholar 

  112. Esser, R.E., Angelo, R.A., Murphey, M.D., Watts, L.M., Thornburg, L.P., Palmer, J.T., Talhouk, J.W. and Smith, R.E., Arthritis Rheum., 37 (1994) 236.

    Google Scholar 

  113. Abrahamson, M., Mason, R.W., Hansson, H., Buttle, D.J., Grubb, A. and Ohlsson, K., Biochem. J., 273 (1991) 621.

    Google Scholar 

  114. Delaisse, J.M., Boyde, A., Maconnachie, E., Ali, N.N., Sear, C.H.J., Eeckhout, Y. and Vaes, G., Bone, 8 (1987) 305.

    Google Scholar 

  115. Bandara, G., Müller, G.M., Galea-Lauri, J., Tindal, M.H., Georgescu, H.I., Suchanek, M.K., Hung, G.L., Glorioso, J.C., Robbins, P.D. and Evans, C.H., Proc. Natl. Acad. Sci. USA, 90 (1993) 10764.

    Google Scholar 

  116. Müller-Ladner, U., Roberts, C.R., Franklin, B.N., Gay, R.E., Robbins, P.D., Evans, C.H. and Gay, S., Arthritis Rheum., 38 (1995) S398.

  117. McKerrow, J.H., Perspect. Drug Discov. Design, 2 (1994) 437.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, 35294, Birmingham, AL, U.S.A.

    Ulf Müller-Ladner, Renate E. Gay & Steffen Gay

  2. Center for Experimental Rheumatology, University Hospital, Gloriastrasse 25, CH-8091, Zürich, Switzerland

    Ulf Müller-Ladner, Renate E. Gay & Steffen Gay

Authors
  1. Ulf Müller-Ladner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Renate E. Gay
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Steffen Gay
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Müller-Ladner, U., Gay, R.E. & Gay, S. Cysteine proteinases in arthritis and inflammation. Perspectives in Drug Discovery and Design 6, 87–98 (1996). https://doi.org/10.1007/BF02174047

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02174047

Keywords

Search

Navigation