Soluble analogs of GalCer and suramin as potential inhibitors of HIV-1 infection: Key role of self-association

Summary

Lesions observed in the brain and intestine of HIV-infected individuals may stem from a direct infection of CD4/GalCer+ cells by the virus within these two organs. HIV-infection of such cells may also facilitate entry of the virus through the intestinal mucosa. Apart from treatment with conventional anti-viral agents, the use of drugs that block interactions between the virus and CD4/GalCer+ cells represents a promising therapeutic strategy in the fight against AIDS. We present here two families of compounds with such activity, namely soluble analogs of GalCer and a family of suramin analogs. The role of self-association is discussed.

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Correspondence to Isabelle Rico-Lattes.

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Guidetti, B., André-Barrès, C., Rico-Lattes, I. et al. Soluble analogs of GalCer and suramin as potential inhibitors of HIV-1 infection: Key role of self-association. Perspectives in Drug Discovery and Design 5, 234–242 (1996). https://doi.org/10.1007/BF02174018

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Keywords

  • Polymer
  • Therapeutic Strategy
  • Potential Inhibitor
  • Intestinal Mucosa
  • Suramin