Skip to main content
SpringerLink
Log in

Intravaginal formulations to prevent HIV infection

  • Part VII. Inhibition Of HIV Entry Into CD4− Cells
  • Published:
Perspectives in Drug Discovery and Design

Summary

The term ‘microbicide’ denotes a vaginal product which could be used to protect an individual from infection by HIV and other sexually transmitted pathogens. This manuscript describes an in vitro model which is based on the mechanism of sexual transmission of HIV, and can be used to screen compounds for anti-HIV activity. An in vitro model forChlamydia is also described. Sulfated polysaccharides are exceedingly effective in blocking infection in both of these in vitro systems. Nevertheless, a formidable amount of animal and clinical work will need to be conducted before it will be clear whether this group of compounds will be efficacious in a product for human use.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. WHO, GPA, RES and SFI, WHO Document, 1 (1992) 8.

    Google Scholar 

  2. Niruthisard, S., Roddy, R.E. and Chutivongse, S., Sex. Transm. Dis., 18 (1991) 176.

    Google Scholar 

  3. Pearce-Pratt, R. and Phillips, D.M., Biol. Reprod., 48 (1993) 431.

    Google Scholar 

  4. Pearce-Pratt, R. and Phillips, D.M., Biol. Reprod., 54 (1996) 173.

    Google Scholar 

  5. Tan, X., Pearce-Pratt, R. and Phillips, D.M., J. Virol., 67 (1993) 6447.

    Google Scholar 

  6. Ganz, T. and Lehrer, R.I., Curr. Opin. Immunol., 6 (1994) 584.

    Google Scholar 

  7. Gallo, R.L., Ono, M., Povsic, T., Page, C., Eriksson, E., Klagsbrun, M. and Bernfield, M., Proc. Natl. Acad. Sci. USA, 91 (1994) 11035.

    Google Scholar 

  8. Harwig, S.S.L., Kokryakov, V.N., Swiderek, K.M., Aleshina, G.M., Zhao, C. and Lehrer, R.I., Febs Lett., 362 (1995) 65.

    Google Scholar 

  9. Scocchi, M., Romeo, D. and Zanetti, M., Febs Lett., 352 (1994) 197.

    Google Scholar 

  10. Agerberth, B., Lee, J.-Y., Bergman, T., Carlquist, M., Boman, H.G., Mutt, V. and Joernvall, H., Eur. J. Biochem., 202 (1991) 849.

    Google Scholar 

  11. Harwig, S.S.L., Swiderek, K.M., Kokryakov, V.N., Tan, L., Lee, T.D., Panyutich, E.A., Aleshina, G.M., Shamova, O.V. and Lehrer, R.I., Febs Lett., 342 (1994) 281.

    Google Scholar 

  12. Portegies, P., Drugs, 49 (1995) 25.

    Google Scholar 

  13. Pizzo, P.A. and Wilfert, C., Pediatr. Aids Hiv Infect., 5 (1994) 273.

    Google Scholar 

  14. Bourinbaiar, A.S. and Lee-Huang, S., Contraception, 49 (1994) 131.

    Google Scholar 

  15. Cone, R.A. and Whaley, K.J., Am. J. Reprod. Immunol., 32 (1994) 114.

    Google Scholar 

  16. Voeller, B. and Anderson, D.J., J. Am. Med. Assoc., 267 (1992) 1917.

    Google Scholar 

  17. Voeller, B. and Anderson, D.J., Topanga Conference, Maripusa Education and Research Foundation, paper no 16, 1992.

  18. Levy, J.A., Am. J. Med., 95 (1993) 86.

    Google Scholar 

  19. Levy, J.A., Microbiol. Rev., 57 (1993) 183.

    Google Scholar 

  20. Clemetson, D.B.A., Moss, G.B., Willerford, D.M., Hensel, M., Emonyi, W., Holmes, K.K., Plummer, F., Ndinya-Achola, J., Roberts, P.L., Hillier, S. and Kreiss, J.K., J. Am. Med. Assoc., 269 (1993) 2860.

    Google Scholar 

  21. Ilaria, G., Jacobs, J.L., Polsky, B., Koll, B., Baron, P., MacLow, C., Armstrong, D. and Schlegel, P.N., Lancet, 340 (1992) 1469.

    Google Scholar 

  22. Mermin, J.H., Holodniy, M., Katzenstein, D.A. and Merigan, T.C., J. Infect. Dis., 164 (1991) 769.

    Google Scholar 

  23. Phillips, D.M., Aids, 8 (1994) 1.

    Google Scholar 

  24. Adachi, A., Koenig, S., Gendelman, H.E., Daugherty, D., Gattoni-Celli, S., Fauci, A.S. and Martin, M.A., J. Virol., 61 (1987) 209.

    Google Scholar 

  25. Zachar, V., Spire, B., Hirsch, I., Chermann, J.C. and Ebbesen, P., J. Virol., 654 (1991) 2102.

    Google Scholar 

  26. Pearce-Pratt, R., Malamud, D. and Phillips, D.M., J. Virol., 68 (1994) 2898.

    Google Scholar 

  27. Phillips, D.M., Zacharopoulos, V.R., Tan, X. and Pearce-Pratt, R., Trends Microbiol., 2 (1994) 454.

    Google Scholar 

  28. Phillips, D.M., Tan, X., Pearce-Pratt, R. and Zacharopoulos, V.R., J. Virol. Methods, 52 (1995) 1.

    Google Scholar 

  29. Nahmias, A.J., Kibrick, S. and Bernfeld, P., Proc. Soc. Exp. Biol. Med., 115 (1964) 993.

    Google Scholar 

  30. Vaheri, A., Acta Pathol. Microbiol. Scand., 171 (1964) 1.

    Google Scholar 

  31. Takemoto, K.K. and Fabisch, P., Proc. Soc. Exp. Biol. Med., 116 (1964) 140.

    Google Scholar 

  32. De Somer, P., De Clercq, E., Billiau, A., Schonne, E. and Claesen, M., J. Virol., 2 (1968) 886.

    Google Scholar 

  33. Baba, M., Snoeck, R., Pauwels, R. and De Clercq, E., Antimicrob. Agents Chemother., 32 (1988) 1742.

    Google Scholar 

  34. Ito, M., Baba, M., Sato, A., Pauwels, R., De Clercq, E. and Shigeta, S., Antiviral Res., 7 (1987) 361.

    Google Scholar 

  35. Mitsuya, H., Looney, D.J., Kuno, S., Ueno, R., Wong-Staal, F. and Broder, S., Science, 240 (1988) 646.

    Google Scholar 

  36. Schols, D., Baba, M., Pauwels, R., Desmyter, J. and De Clercq, E., Proc. Natl. Acad. Sci. USA, 86 (1989) 3322.

    Google Scholar 

  37. Schols, D., Pauwels, R., Desmyter, J. and De Clercq, E., Virology, 175 (1990) 556.

    Google Scholar 

  38. Looney, D.J., Hayashi, S., Nicklas, H., Redfield, R.F., Broder, S., Wong-Staal, F. and Mitsuya, H., J. Aids, 3 (1990) 649.

    Google Scholar 

  39. McClure, M.O., Moore, J.P. and Blac, D.G., Aids Res. Hum. Retroviruses, 8 (1992) 19.

    Google Scholar 

  40. Bagasra, O. and Lischner, H.W., J. Infect. Dis., 158 (1988) 1058.

    Google Scholar 

  41. Baba, M., Schols, D., Pauwels, R., Nakashima, H. and De Clercq, E., J. Aids, 3 (1990) 493.

    Google Scholar 

  42. Nakashima, H., Yoshida, O., Tochikura, T.S. and Yoshida, T., Jpn. J. Cancer Res., 78 (1987) 1164.

    Google Scholar 

  43. Sydow, G. and Kloecking, H.P., Biomed. Biochem. Acta, 46 (1987) 527.

    Google Scholar 

  44. Ueno, R. and Kuno, S., Lancet, 7 (1987) 1379.

    Google Scholar 

  45. Gama Sosa, M.A., Fazely, F., Koch, J.A., Vercellotti, S.V. and Ruprecht, R.M., Biochem. Biophys. Res. Commun., 174 (1991) 489.

    Google Scholar 

  46. Moelling, K., Schulze, T. and Diringer, H., J. Virol., 63 (1989) 5489.

    Google Scholar 

  47. Tan, X. and Phillips, D.M., Arch. Virol., (1996) in press.

  48. Miller, C.J., Alexander, N.J., Sutjipto, S. and Joye, S.M., J. Med. Primatol., 19 (1990) 401.

    Google Scholar 

  49. Miller, C.J., Alexander, N.J., Gettie, A., Hendrickx, A.G. and Marx, P.A., Fertil. Steril., 57 (1992) 1126.

    Google Scholar 

  50. Roddy, R.E., Cordero, M., Cordero, C. and Fortney, J.A., Int. J. Std. Aids, 4 (1993) 165.

    Google Scholar 

  51. Oka, T., Sonobe, H., Iwata, J., Kubonishi, I., Satoh, H., Takata, M., Tanaka, Y., Tateno, M., Tozawa, H., Mori, S., Yoshiki, T. and Ohtsuki, Y., J. Virol., 66 (1992) 6686.

    Google Scholar 

  52. Seto, A., Kawanishi, M., Matsuda, S. and Ogawa, K., J. Exp. Med., 168 (1988) 2409.

    Google Scholar 

  53. Yamanouchi, K., Kinoshita, K., Moriuchi, R., Katamine, S., Amagasaki, T., Ikeda, S., Ichimaru, M., Miyamoto, T. and Hino, S., Jpn. J. Cancer Res., 76 (1985) 481.

    Google Scholar 

  54. Kreiss, J., Ngugi, E. and Holmes, K., J. Am. Med. Assoc., 268 (1992) 477.

    Google Scholar 

  55. Feldblum, P., VIIIth International Conference on AIDS, Amsterdam, The Netherlands, July 1992, Abstract WeC-1085, p. 8(1).

  56. Zekeng, L., Feldblum, P.J., Oliver, R.M. and Kaptue, L., Aids, 7 (1993) 725.

    Google Scholar 

  57. Elias, C.J. and Heise, L.L., Aids, 8 (1994) 1.

    Google Scholar 

  58. Zaretzky, F.R., Pearce-Pratt, R. and Phillips, D.M., Infect. Immun., 63 (1995) 3520.

    Google Scholar 

  59. Louv, W.C., Austin, H., Alexander, W.J., Stagno, S. and Cheeks, J., J. Infect. Dis., 158 (1988) 518.

    Google Scholar 

  60. Niruthisard, S., Roddy, R.E. and Chutivonse, S., Lancet, 339 (1992) 1371.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. The Population Council, 1230 York Avenue, 10021, New York, NY, USA

    David M. Phillips

Authors
  1. David M. Phillips
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Phillips, D.M. Intravaginal formulations to prevent HIV infection. Perspectives in Drug Discovery and Design 5, 213–224 (1996). https://doi.org/10.1007/BF02174016

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02174016

Keywords

Search

Navigation