Intravaginal formulations to prevent HIV infection

Summary

The term ‘microbicide’ denotes a vaginal product which could be used to protect an individual from infection by HIV and other sexually transmitted pathogens. This manuscript describes an in vitro model which is based on the mechanism of sexual transmission of HIV, and can be used to screen compounds for anti-HIV activity. An in vitro model forChlamydia is also described. Sulfated polysaccharides are exceedingly effective in blocking infection in both of these in vitro systems. Nevertheless, a formidable amount of animal and clinical work will need to be conducted before it will be clear whether this group of compounds will be efficacious in a product for human use.

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Phillips, D.M. Intravaginal formulations to prevent HIV infection. Perspectives in Drug Discovery and Design 5, 213–224 (1996). https://doi.org/10.1007/BF02174016

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Keywords

  • Polymer
  • Sulfated
  • Polysaccharide
  • Clinical Work
  • Sexual Transmission