HIV-permissive cells from solid tissues: Cytokine induction and effects

Summary

HIV-1 is a polytropic virus that, apart from hematopoietic cells, can replicate in several cells from solid tissues. Virus yields vary widely, closely resembling differences in HIV binding to the cells; the latter phenomenon appears mainly related to the extent of CD4 expression, even though other molecules have been implied in virus-cell interactions, the expression of which on the cell membrane can be modulated by several stimuli. During the course of HIV replication, a series of cytokines is produced and released in parallel to virus growth, particularly IL-6 and TNF-α. In fact, exposure of fibroblasts or epithelial cells to these HIV-in-duced cytokines causes an increase of CD4 expression, HIV adsorption to uninfected cells, and release of infectious virions by infected cells. In cells exposed to interferon-γ, IL-6 and TNF-α allow the virus to bypass interferon inhibition of virus release. The fact that HIV-1 adsorption and spread can be mediated by HIV-induced cytokines may be relevant in AIDS pathogenesis, accelerating virus transmission both within the organ and to infiltrating cells, activating a self-maintaining mechanism of infection.

This is a preview of subscription content, access via your institution.

References

  1. 1

    Fust, G., Dierich, M.P. and Hidvegi, T., Immunol. Today, 16 (1995) 167.

    Google Scholar 

  2. 2

    Romagnani, S., Del Prete, G., Manetti, R., Ravina, A., Annunziato, F., De Carli, M., Mazzetti, M., Piccinni, M.P., D'Elios, M.M., Parronchi, P., Sampognaro, S. and Maggi, E., Immunol. Rev., 140 (1994) 73.

    Google Scholar 

  3. 3

    Bentwich, Z., Kalinkovich, A. and Weisman, Z., Immunol. Today, 16 (1995) 187.

    Google Scholar 

  4. 4

    Levy, J.A., HIV and the Pathogenesis of AIDS, ASM Press, Washington, DC, 1994.

    Google Scholar 

  5. 5

    Greene, W.C., New Engl. J. Med., 324 (1991) 308.

    Google Scholar 

  6. 6

    Chowdhury, M.I.H., Munataka, T., Koyanagy, Y., Kobayashi, S., Arai, S. and Yamamoto, N., Biochem. Biophys. Res. Commun., 170 (1990) 1365.

    Google Scholar 

  7. 7

    Mosca, J.D., Bednarik, D.P., Raj, N.B.K., Rosen, C.A., Sodroski, C.A., Haseltine, W.A. and Pitha, P., Nature, 325 (1987) 67.

    Google Scholar 

  8. 8

    Roulston, A., Lin, R., Beauparlant, P., Wainberg, M.A. and Hiscott, J., Microbiol. Rev., 59 (1995) 481.

    Google Scholar 

  9. 9

    Vicenzi, E., Turchetto, L., Ruggieri, A. and Poli, G., Semin. Clin. Immunol., 9 (1995) 31.

    Google Scholar 

  10. 10

    Dolei, A., Serra, C., Arca, M.V. and Toniolo, A., Aids, 6 (1992) 232.

    Google Scholar 

  11. 11

    Plata, F., Garcia-Pons, F., Ryter, A., Lebargy, F., Goodenow, M.M., Dat, M.H.Q., Autran, B. and Mayaud, C., Aids Res. Hum. Retroviruses, 6 (1990) 979.

    Google Scholar 

  12. 12

    Tateno, M., Gonzalez-Scarano, F. and Levy, J.A., Proc. Natl. Acad. Sci. USA, 86 (1989) 4287.

    Google Scholar 

  13. 13

    Mellert, W., Kleinschmidt, A., Schmidt, J., Festl, H., Emler, S., Roth, W.K. and Erfle, V., Aids, 4 (1990) 527.

    Google Scholar 

  14. 14

    Dolei, A., Serra, C., Arca, M.V., Tilocca, F., Riva, E., Antonelli, G., Dianzani, F. and Toniolo, A., Aids Res. Hum. Retroviruses, 10 (1994) 1089.

    Google Scholar 

  15. 15

    Nelson, J.A., Wiley, C.A., Reynolds-Kohler, C., Reese, C.E., Margaretten, W. and Levy, J.A., Lancet 1, (1988) 259.

    Google Scholar 

  16. 16

    Yahi, N., Baghdiguian, S., Bolmont, C. and Fantini, J., J. Acquired Immune Defic. Syndr., 5 (1992) 993.

    Google Scholar 

  17. 17

    Toniolo, A., Serra, C., Conaldi, C., Basolo, F., Falcone, V. and Dolei, A., Aids, 9 (1995) 859.

    Google Scholar 

  18. 18

    Nottet, H.S.L.M., Janse, I., De Graaf, L., Bakker, L.J., Visser, M.R. and Verhoef, J., J. Med. Virol., 40 (1993) 39.

    Google Scholar 

  19. 19

    Barboza, A., Castro, B.A., Whalen, M., Moore, C.C.D., Parkin, J.S., Miller, W.L., Gonzalez-Scarano, F. and Levy, J.A., Aids, 6 (1992) 1437.

    Google Scholar 

  20. 20

    Cao, Y., Friedman-Kien, A.E., Huang, Y., Li, X.L., Mirabile, M., Moudgil, T., Zucker-Franklin, D. and Ho, D.D., J. Virol., 64 (1990) 2553.

    Google Scholar 

  21. 21

    Clapham, P.R., Weber, J.N., Whitby, D., McIntosh, K., Dalgleish, A.G., Maddon, P.J., Deen, K.C., Sweet, R.W. and Weiss, R.A., Nature, 337 (1989) 368.

    Google Scholar 

  22. 22

    Li, X.L., Moudgil, T., Vinters, H.V. and Ho, D.D., J. Virol., 64 (1990) 1383.

    Google Scholar 

  23. 23

    Ensoli, F., Cafaro, A., Fiorelli, V., Vannelli, B., Ensoli, B. and Thiele, C., Virology, 210 (1995) 221.

    Google Scholar 

  24. 24

    Re, M.C., Furlini, G., Cenacchi, G., Preda, P. and La Placa, M., Microbiologica, 14 (1991) 149.

    Google Scholar 

  25. 25

    Steffan, A.M., Lafon, M.E., Gendrault, J.L., Schweitzer, C., Royer, C., Jaeck, D., Arnaud, J.P., Schmitt, M.P., Aubertin, A.M. and Kirn, A., Proc. Natl. Acad. Sci. USA, 89 (1992) 1582.

    Google Scholar 

  26. 26

    Scheglovitova, O., Capobianchi, M.R., Antonelli, G., Guamnu, D. and Dianzani, F., Arch. Virol., 132 (1993) 267.

    Google Scholar 

  27. 27

    Conaldi, P.G., Serra, C., Dolei, A., Basolo, F., Falcone, V., Mariani, G., Speziale, P. and Toniolo, A., J. Med. Virol., 47 (1995) 355.

    Google Scholar 

  28. 28

    Poland, S.D., Rice, G.P.A. and Debakan, G.A., J. Acquired Immune Defic. Syndr., 8 (1995) 437.

    Google Scholar 

  29. 29

    Fazely, F., Fry, G.N., Thirkill, T.L., Hakim, H., King, B.F. and Douglas, G.C., Aids Res. Hum. Retroviruses, 11 (1995) 1023.

    Google Scholar 

  30. 30

    Lewis, S.H., Reynolds-Koheler, C., Fox, H.E. and Nelson, J.A., Lancet, 335 (1990) 565.

    Google Scholar 

  31. 31

    Zachar, V., Norskov-Lauritsen, N., Juhl, C., Spire, B., Chermann, J.C. and Ebbesen, P., J. Gen. Virol., 72 (1991) 1253.

    Google Scholar 

  32. 32

    da Silva, M., Shevchuck, M.M., Cronin, W.J., Armenakas, N.A., Tannenbaum, M., Fracchia, J.A. and Ioachim, H.L., Am. J. Clin. Pathol., 93 (1989) 196.

    Google Scholar 

  33. 33

    Scofield, V.L., Rao, B., Broder, S., Kennedy, C., Wallace, M., Graham, B. and Poiesz, B.J., Aids, 8 (1994) 1733.

    Google Scholar 

  34. 34

    Cohen, A.H., Sun, N.C.J., Shapshak, P. and Imagawa, D.T., Mod. Pathol., 2 (1989) 125.

    Google Scholar 

  35. 35

    Roederer, M., Staal, F.J., Raju, P.A., Ela, S.W. and Herzenberg, L.A., Proc. Natl. Acad. Sci. USA, 87 (1990) 4884.

    Google Scholar 

  36. 36

    Green, D.F., Resnick, L. and Bourgoignie, J.J., Kidney Int., 41 (1992) 956.

    Google Scholar 

  37. 37

    Lipshultz, S.E., Fox, C.H., Perez-Atayde, A.R., Sanders, S.P., Colan, S.D., McIntosh, K. and Winter, H.S., Am. J. Cardiol., 66 (1990) 246.

    Google Scholar 

  38. 38

    Espinoza, L., Aguilar, J.L., Espinoza, C.G., Berman, A., Gutierrez, F., Vasey, F.B. and Germain, B.F., J. Rheumatol., 17 (1990) 1195.

    Google Scholar 

  39. 39

    Chesebro, B. and Wehrly, K., J. Virol., 62 (1988) 3779.

    Google Scholar 

  40. 40

    Yahi, N., Baghdiguian, S., Moreau, H. and Fantini, J., J. Virol., 66 (1992) 4848.

    Google Scholar 

  41. 41

    Callebaut, C., Krust, B., Jacotot, E. and Hovanessian, A.G., Science, 262 (1993) 2045.

    Google Scholar 

  42. 42

    Oravecz, T., Roderiquez, G., Koffi, J., Wang, J., Ditto, M., Chequer Bou-Habib, D., Lusso, P. and Norcross, M.A., Nature Med., 1 (1995) 919.

    Google Scholar 

  43. 43

    Arthur, L.A., Bess, J.W., Sowder, R.C., Benveniste, R.E., Mann, D.L., Chermann, J.C. and Henderson, L.E., Science, 258 (1992) 1935.

    Google Scholar 

  44. 44

    Capobianchi, M.R., Serra, C., Abbate, I., Marongiu, P., Castilletti, C., Tilocca, F., Dianzani, F. and Dolei, A., Aids, 8 (1994) 1731.

    Google Scholar 

  45. 45

    Vitkovic, L., Wood, G.P., Major, E.O. and Fauci, A.S., Aids Res. Hum. Retroviruses, 7 (1991) 723.

    Google Scholar 

  46. 46

    Merrill, J.E., Koyanagi, Y., Zack, J., Thomas, L., Martin, F. and Chen, I.S.Y., J. Virol., 66 (1992) 2217.

    Google Scholar 

  47. 47

    Tornatore, C., Nath, A., Amemya, K. and Major, E., J. Virol., 65 (1991) 6094.

    Google Scholar 

  48. 48

    Ameglio, F., Tilocca, F., Arca, M.V., Alemanno, L. and Dolei, A., Aids Res. Hum. Retroviruses, 9 (1993) 795.

    Google Scholar 

  49. 49

    Dolei, A., Arca, M.V., Tilocca, F., Pietravalle, M., Alemanno, L., Toniolo, A. and Ameglio, F., Arch. Virol., 134 (1994) 157.

    Google Scholar 

  50. 50

    Basolo, F., Serra, C., Ciardiello, F., Russo, J., Campani, A., Dolei, A., Squartini, F. and Toniolo, A., Int. J. Cancer, 51 (1992) 634.

    Google Scholar 

  51. 51

    Rosenberg, Z.F. and Fauci, A.S., Immunol. Today, 11 (1990) 176.

    Google Scholar 

  52. 52

    Dolei, A., Serra, C., Arca, M.V. and Toniolo, A., J. Res., 10 (1990) S107.

  53. 53

    Dolei, A., Serra, C., Tilocca, F., Marongiu, P., Curreli, S., Modesti, A., Toniolo, A. and Ameglio, F., J. Interferon Res., 14 (1994) S200.

  54. 54

    Ameglio, F., Tosi, R., Tanigaki, N. and Dolei, A., In Solheim, B.G., Moller, E. and Ferrone, S. (Eds.) HLA class II Antigens, Springer, Berlin, 1985, pp. 299–313.

    Google Scholar 

  55. 55

    Buonaguro, L., Barillari, G., Chang, H.K., Bohan, C.A., Kao, V., Morgan, R., Gallo, R.C. and Ensoli, B., J. Virol., 66 (1992) 7159.

    Google Scholar 

  56. 56

    Serra, C., Marongiu, P., Biolchini, A., Curreli, S., Ameglio, F. and Dolei, A., J. Interferon Cytokine Res., 15 (1995) S187.

  57. 57

    Barillari, G., Buonaguro, L., Fiorelli, V., Hoffman, J., Michaels, F., Gallo, R.C. and Ensoli, B., J. Immunol., 149 (1992) 3727.

    Google Scholar 

  58. 58

    Bhat, S., Spitalnik, S.L., Gonzalez-Scarano, F. and Silberberg, D.H., Proc. Natl. Acad. Sci. USA, 88 (1991) 7131.

    Google Scholar 

  59. 59

    Ikeuchi, K., Kim, S., Byrn, R.A., Goldring, S.R. and Groopman, J.E., J. Virol., 64 (1990) 4226.

    Google Scholar 

  60. 60

    Poli, G.A., Kinter, L. and Fauci, A.S., Proc. Natl. Acad. Sci. USA, 91 (1994) 108.

    Google Scholar 

  61. 61

    Matsuyama, T., Kobayashi, N. and Yamamoto, N., Aids, 5 (1991) 1405.

    Google Scholar 

  62. 62

    Schuitemaker, H., Kootstra, N.A., Koppelman, M.H., Bruisten, S.M., Huisman, H.G., Tersmette, M. and Miedema, F., J. Clin. Invest., 89 (1992) 1154.

    Google Scholar 

  63. 63

    Osborn, L., Kunkel, S. and Nabel, G.J., Proc. Natl. Acad. Sci. USA, 86 (1989) 2336.

    Google Scholar 

  64. 64

    Folks, T.M., Justement, J.S., Kinter, A., Dinarello, C.A. and Fauci, A.S., Science, 238 (1987) 800.

    Google Scholar 

  65. 65

    Novak, R.M., Holzer, T.J., Kennedy, M.M., Heynen, C.A. and Dawson, G., Aids Res. Hum. Retroviruses, 6 (1990) 973.

    Google Scholar 

  66. 66

    Dolei, A., Fattorossi, A., D'Amelio, R., Aiuti, F. and Dianzani, F., J. Interferon Res., 6 (1986) 543.

    Google Scholar 

  67. 67

    Castilletti, C., Capobianchi, M.R., Gentile, M., Abbate, I., Barresi, C., Fais, S., Gelderblom, H. and Dianzani, F., J. Interferon Cytokine Res., 15 (1995) S192.

  68. 68

    Poli, G., Kinter, A.L., Justement, J.S., Bressler, P., Kehrl, J.H. and Fauci, A.S., J. Exp. Med., 173 (1991) 589.

    Google Scholar 

  69. 69

    Pitha, P.M., J. Interferon Res., 11 (1991) 313.

    Google Scholar 

  70. 70

    Kootstra, N.A., Van 't Wout, A.B., Huisman, H.G., Miedema, F. and Schuitemaker, H., J. Virol., 68 (1994) 6967.

    Google Scholar 

  71. 71

    Montaner, L.J., Doyle, A.G., Collin, M., Herbein, G., Illei, P., James, W., Minty, A., Caput, D., Ferrara, P. and Gordon, S., J. Exp. Med., 178 (1993) 743.

    Google Scholar 

  72. 72

    Mackewicz, C.E., Ortega, H. and Levy, J.A., J. Clin. Invest., 87 (1994) 1462.

    Google Scholar 

  73. 73

    Note added in proof: after submission of this paper, four chemokines produced by CD8+ lymphocytes have been found to inhibit HIV: RANTES, MIP-1α and MIP-1β [Cocchi, F., De Vico, A.L., Garzino-Demo, A. Arya, S.K. Gallo, R.C. and Lusso, P., Science, 270 (1995) 1811] and IL-16 [Bayer, M., Werner, A., Bannert, N., Metzner, K. and Kurth, R., Nature, 378 (1995) 563].

    Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to A. Dolei.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Dolei, A., Serra, C., Biolchini, A. et al. HIV-permissive cells from solid tissues: Cytokine induction and effects. Perspectives in Drug Discovery and Design 5, 93–102 (1996). https://doi.org/10.1007/BF02174005

Download citation

Keywords

  • Interferon
  • Infiltrate Cell
  • Infectious Virion
  • Virus Transmission
  • Uninfected Cell