HIV-1 infection of a CD4-negative primary cell type: The oligodendrocyte

Summary

HIV-1 infection of CD4-negative cells has been described both in vitro and in vivo. Two closely related glycolipids, galactosylceramide (GalCer) and 3′-sulfo-galactosylceramide (GalS), have been proposed as potential alternative cellular receptors for HIV-1. Human adult cultured oligodendrocytes are CD4-negative/GalCer-positive cells that are infected by HIV-1 in vitro, resulting in the presence of stable HIV-1 DNA sequences and the production of virus [Albright et al., Virology, (1996) in press]. The in vivo relevance and the effects of HIV infection on oligodendrocyte biology need to be studied further.

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Abbreviations

PCR:

polymerase chain reaction

References

  1. 1

    Adachi, A., Koenig, S., Gendelman, H.E., Daugherty, D., Gattoni-Celli, S., Fauci, A.S. and Martin, M.M., J. Virol., 61 (1987) 209.

    Google Scholar 

  2. 2

    Chiodi, F., Fuerstenberg, S., Gidlund, M., Asjo, B. and Fenyo, E.M., J. Virol., 61 (1987) 1244.

    Google Scholar 

  3. 3

    Koyanagi, Y., Miles, S., Mitsuyasu, R.T., Merrill, J.E., Vinters, H.V., Chen, I.S.Y., Science, 236 (1987) 819.

    Google Scholar 

  4. 4

    Dewhurst, S., Bresser, J., Stevenson, M., Sakai, K., Evinger-Hodges, M.J. and Volsky, D.J., Febs Lett., 213 (1987) 138.

    Google Scholar 

  5. 5

    Cheng-Mayer, C., Rutka, J.T., Rosenblum, M.L., McHugh, T., Stites, D.P. and Levy, J., Proc. Natl. Acad. Sci. USA, 84 (1987) 3526.

    Google Scholar 

  6. 6

    Popovic, M., Mellert, W., Erfle, V. and Gartner, S., Ann. Neurol., 23 (1988) 74.

    Google Scholar 

  7. 7

    Harouse, J.M., Kunsch, C., Hartle, H.T., Laughlin, M.A., Hoxie, J.A., Wigdahl, B. and González-Scarano, F., J. Virol., 63 (1989) 2527.

    Google Scholar 

  8. 8

    Clapham, P.R., Weber, J.N., Whitby, D., McIntosh, K., Dalgleish, A.G., Maddon, P.J., Deen, K.C., Sweet, R.W. and Weiss, R.A., Nature, 337 (1989) 368.

    Google Scholar 

  9. 9

    Tateno, M., González-Scarano, F. and Levy, J.A., Proc. Natl. Acad. Sci. USA, 86 (1989) 4287.

    Google Scholar 

  10. 10

    Li, X.L., Moudgil, T., Vinters, H.V. and Ho, D.D., J. Virol., 64 (1990) 1383.

    Google Scholar 

  11. 11

    Cao, Y., Friedman-Kien, A.E., Huang, Y., Li, X.L., Mirabile, M., Moudgil, T., Zucker-Franklin, D. and Ho, D.D., J. Virol., 64 (1990) 2553.

    Google Scholar 

  12. 12

    Zachar, V., Spire, B., Hirsch, I., Chermann, J.C. and Ebbesen, P., J. Virol., 65 (1991) 2102.

    Google Scholar 

  13. 13

    Kohleisen, B., Neumann, M., Herrmann, R., Brack-Werner, R., Krohn, K.J.E., Ovod, V., Ranki, A. and Erfle, V., Aids, 6 (1992) 1427.

    Google Scholar 

  14. 14

    Barboza, A., Castro, B.A., Whalen, M., Moore, C.C.D., Parkin, J.S., Miller, W.L., González-Scarano, F. and Levy, Aids, 6 (1992) 1437.

    Google Scholar 

  15. 15

    Albright, A.V., Strizki, J.M., Harouse, J.M., O'Connor, M., Lavi, E. and González-Scarano, F., Virology, 217 (1996) 211.

    Google Scholar 

  16. 16

    Patterson, S. and Knight, S.C., J. Gen. Virol., 68 (1987) 1177.

    Google Scholar 

  17. 17

    Wigdahl, B., Guyton, R.A. and Sarin, P.S., Virology, 159 (1987) 440.

    Google Scholar 

  18. 18

    Christofinis, G., Papadaki, L., Sattentau, Q., Ferns, R.B. and Tedder, R., Aids, 1 (1987) 229.

    Google Scholar 

  19. 19

    Tornatore, C., Nath, A., Amemiya, K. and Major, E.O., J. Virol., 65 (1991) 6094.

    Google Scholar 

  20. 20

    Ranki, A., Nyberg, M., Ovod, V., Haltia, M., Elovaara, I., Raininko, R., Haapasalo, H. and Krohn, K., Aids, 9 (1995) 1001.

    Google Scholar 

  21. 21

    Saito, Y., Sharer, L.R., Epstein, L.G., Michaels, J., Mintz, M., Louder, M., Golding, K., Cvetkovich, T.A. and Blumber, B.M., Neurology, 44 (1994) 474.

    Google Scholar 

  22. 22

    Tornatore, C., Chandra, R., Berger, J. and Major, E.O., Neurology, 44 (1994) 481.

    Google Scholar 

  23. 23

    Nuovo, G.J., Gallery, F., MacConnell, P. and Braun, A., Am. J. Pathol., 144 (1994) 659.

    Google Scholar 

  24. 24

    Harouse, J., Bhat, S., Spitalnik, S., Laughlin, M.A., Stefano, K., Silberberg, D. and González-Scarano, F., Science, 245 (1991) 320.

    Google Scholar 

  25. 25

    Yahi, N., Baghdiguian, S., Moreau, H. and Fantini, J., J. Virol., 66 (1992) 4848.

    Google Scholar 

  26. 26

    Fantini, J., Cook, D.G., Nathanson, N., Spitalnik, S.L. and González-Scarano, F., Proc. Natl. Acad. Sci. USA, 90 (1993) 2700.

    Google Scholar 

  27. 27

    Cook, D.G., Fantini, J., Spitalnik, S.L. and González-Scarano, F., Virology, 201 (1994) 206.

    Google Scholar 

  28. 28

    Yahi, N., Sabatier, J.-M., Baghdiguian, S., González-Scarano, F. and Fantini, J., J. Virol., 69 (1995) 320.

    Google Scholar 

  29. 29

    Harouse, J.M., Collman, R.G. and González-Scarano, F., J. Virol., 69 (1995) 7383.

    Google Scholar 

  30. 30

    Dragic, T., Picard, L. and Alizon, M., J. Virol., 69 (1995) 1013.

    Google Scholar 

  31. 31

    DeVries, G.H. and Norton, W.T., J. Neurochem., 22 (1974) 259.

    Google Scholar 

  32. 32

    Siegel, G.J., Agranoff, B.W., Albers, R.W. and Molinoff, P.B. (Eds.) Basic Neurochemistry, Raven Press, New York, NY, 1994, p. 106.

    Google Scholar 

  33. 33

    Kawanami, J. and Tsuji, T., Jpn. J. Exp. Med., 38 (1968) 123.

    Google Scholar 

  34. 34

    Levine, M., Bain, J., Narashimhan, R., Palmer, B., Yates, A.J. and Murray, R.K., Biochim. Biophys. Acta, 441 (1976) 134.

    Google Scholar 

  35. 35

    Martensson, E., Acta Chem. Scand., 17 (1963) 1174.

    Google Scholar 

  36. 36

    Esiri, M.M., Morris, C.S. and Millard, P.R., Aids, 5 (1991) 1081.

    Google Scholar 

  37. 37

    Navia, B.M., Cho, E.S., Petito, C.K. and Price, R.W., Ann. Neurol., 19 (1986) 525.

    Google Scholar 

  38. 38

    Gabuzda, D.H., Ho, D.D., de la Monte, S.M., Hirsch, M.S., Rota, T.R. and Sobel, R.A., Ann. Neurol., 20 (1986) 289.

    Google Scholar 

  39. 39

    Wiley, C.A., Schrier, R.D., Nelson, J.A., Lampert, P.W. and Oldstone, M.B.A., Proc. Natl. Acad. Sci. USA, 83 (1986) 7089.

    Google Scholar 

  40. 40

    Glass, J.D., Wesselingh, S.L., Selnes, O.A. and McArthur, J.C., Neurology, 43 (1993) 2230.

    Google Scholar 

  41. 41

    Power, C., Kong, P.A., Crawford, T.O., Wesseling, S., Glass, J.D., McArthur, J.C. and Trapp, B.D., Ann. Neurol., 34 (1993) 339.

    Google Scholar 

  42. 42

    Ranscht, B., Clapshaw, P.A., Price, J., Noble, M. and Seifer, W., Proc. Natl. Acad. Sci. USA, 79 (1982) 2709.

    Google Scholar 

  43. 43

    Chesebro, B. and Wehrly, K., J. Virol., 62 (1988) 3779.

    Google Scholar 

  44. 44

    Budka, H., Wiley, C.A., Kleihues, P., Artigas, J., Asbury, A.K., Cho, E.S., Cornblath, D.R., Dal Canto, M.C., DeGirolami, U. and Dickson, D., Brain Pathol., 1 (1991) 143.

    Google Scholar 

  45. 45

    Glass, J.D., Fedor, H., Wesselingh, S.L. and McArthur, J.C., Ann. Neurol., 38 (1995) 755.

    Google Scholar 

  46. 46

    Wiley, C.A. and Achim, C., Ann. Neurol., 36 (1994) 673–676.

    Google Scholar 

  47. 47

    Brew, B.J., Rosenblum, M., Cronin, K. and Price, R.W., Ann. Neurol., 38 (1995) 563.

    Google Scholar 

  48. 48

    Wiley, C.A. and Achim, C.L., Ann. Neurol., 38 (1995) 559.

    Google Scholar 

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Correspondence to Francisco González-Scarano.

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Albright, A.V., Lavi, E., O'Connor, M. et al. HIV-1 infection of a CD4-negative primary cell type: The oligodendrocyte. Perspectives in Drug Discovery and Design 5, 43–50 (1996). https://doi.org/10.1007/BF02174000

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Keywords

  • Polymer
  • Primary Cell
  • Cellular Receptor
  • Primary Cell Type
  • Related Glycolipid