Summary
During osmotic hemolysis in the presence of heparin there is a marked increase in the viscosity of the cell suspension, which reaches its maximum only at a certain, fixed ratio of cell quantity to heparin. The increase in viscosity is accompanied by modifications of the structure of the cell nuclei. This process appears to affect the anticoagulant activity of heparin in a certain manner.
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Kradolfer, F. Einfluss von Antikoagulantien auf Zellkernproteine. Experientia 8, 186–187 (1952). https://doi.org/10.1007/BF02173736
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DOI: https://doi.org/10.1007/BF02173736