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Zum Einfluß von systemischer Digitalis-Applikation auf den intraocularen Druck

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The intraocular pressure (IOP) often healthy subjects was measured before and after a 2-week systemic application of beta-methyldigoxin. The drug led to a highly significant decrease of IOP of on the average 2 mm Hg. The decrease was independent of the blood concentration of glycoside — at least within the therapeutic range. There was a positive correlation between IOP before digoxin application and the subsequent IOP decrease. The rate of outflow increased, but not significantly. Implications for the therapy of glaucoma are briefly discussed.


An 10 gesunden Probanden wurde der Augendruck vor und nach 14tägiger systemischer Gabe von Beta-Methyl-Digoxin gemessen. Es fand sich eine hochsignifikante Verringerung des intraocularen Druckes um durchschnittlich 2 mm Hg, die innerhalb der therapeutischen Breite nicht von der Serumglykosidkonzentration abhing. Die drucksenkende Wirkung war im Durchschnitt um so stärker, je höher der Ausgangsdruck lag. Die tonographisch gemessene Abflußleichtigkeit nahm zu (jedoch nicht significant). Implikationen für die Glaukomtherapie werden kurz diskutiert.

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Hardt, B.W., Johnen, R. & Fahle, M. Zum Einfluß von systemischer Digitalis-Applikation auf den intraocularen Druck. Graefe's Arch Clin Exp Ophthalmol 219, 76–79 (1982).

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