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Hypotony and experimental rubeosis iridis in primate eyes

A clinicopathologic study

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Abstract

Rubeosis iridis was produced in cynomolgus monkeys by subjecting their eyes to severe surgically induced hypotony. New vessels on the iris showed characteristic fenestrations of endothelial cell walls as well as mitotic activity.

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References

  • Aaberg TA, Van Horn DL (1978) Late complications of pars plana vitreous surgery. Trans Am Acad Ophthalmol Otolaryngol 85:126–139

    Google Scholar 

  • Ashton N (1957) Retinal vascularization in health and disease. Am J Ophthalmol 44:7–17

    Google Scholar 

  • Ashton N (1962) Neovascularizations in ocular disease. Trans Ophthalmol Soc UK 81:145–161

    Google Scholar 

  • BenEzra D (1978) Neovasculogenic ability of prostaglandins, growth factors, and synthetic chemoattractants. Am J Ophthalmol 86:455–461

    Google Scholar 

  • Braendtrup P (1950) Central vein thrombosis and hemorrhagic glaucoma. Acta Ophthalmol [Suppl] 35:1–162

    Google Scholar 

  • Dietrich WD, Bursto R, Grinsberg MD (1982) Endothelial microvilli produced by diffuse cerebral ischemia. In: Society of Neuroscience Abstracts, vol 8, part 2. 12th Annual Meeting, Minneapolis, October 31–November 5, 1982. Society for Neuroscience, Bethesda, p 1007

    Google Scholar 

  • Gartner S, Henkind P (1978) Neovascularization of the iris (rubeosis iridis). Surv Ophthalmol 22:291–312

    Google Scholar 

  • Hayreh SS, March W, Phelps CD (1978a) Ocular hypotony following retinal vein occlusion. Arch Ophthalmol 96:827–833

    Google Scholar 

  • Hayreh SS, van Heuven WAJ, Hayreh MS (1978b) Experimental retinal vascular occlusion. I. Pathogenesis of central retinal vein occlusion. Arch Ophthalmol 96:311–323

    Google Scholar 

  • Hazama F, Amano S, Ozaki T (1978) Pathological changes of cerebral vessels endothelial cells in spontaneously hypertensive rats, with special reference to the role of the cells in the development of hypertensive cerebrovascular lesions. In: Cervos-Navarro J, Betz E, Ebhardt G, Ferszt R, Williamweber R (eds) Pathology of cerebro-spinal microcirculation advances in neurology, vol 20. Raven, New York, pp 359–369

    Google Scholar 

  • Hazama F, Ozaki T, Amano S (1979) Scanning electron microscopic study of endothelial cells of cerebral arteries from spontaneously hypertensive rats. Stroke 10:245–252

    Google Scholar 

  • Imre G (1970) Rubeosis iridis. Acta Med Sci Hung 27:205–207

    Google Scholar 

  • Kottow M, Wassilewa P, Hendrickson P (1975) Provoked iris ischemia in the rabbit: a fluorescein angiographic study. Can J Ophthalmol 10:255–262

    Google Scholar 

  • Madsen PH (1971a) Haemorrhagic glaucoma: comparative study in diabetic and non-diabetic patients. Br J Ophthalmol 55:444–450

    Google Scholar 

  • Madsen PH (1971b) Rubeosis of the iris and haemorrhagic glaucoma in patients with proliferative diabetic retinopathy. Br J Ophthalmol 55:368–371

    Google Scholar 

  • Moore RF (1924) Retinal venous thrombosis. George Putman and Sons, London

    Google Scholar 

  • Packer AJ, Tse DT, Gux Q, Hayreh SS (1984) Hematoporphyrin photoradiation therapy for iris neovascularization: a preliminary report. Arch Ophthalmol 102:1193–1197

    Google Scholar 

  • Perraut LE, Zimmerman LE (1959) The occurrence of glaucoma following occlusion of the central retinal artery. Arch Ophthalmol 61:845–867

    Google Scholar 

  • Peyman GA, Huamonte FU, Goldberg MF, Sanders DR, Nagpal KC, Raichand M (1978) Four hundred consecutive pars plana vitrectomies with the vitrophage. Arch Ophthalmol 96:45–50

    Google Scholar 

  • Povlischork JT, Becker DP, Sullivan KG, Miller JD (1978) Vascular permeability alterations to horseradish peroxidase in experimental brain injury. Brain Res 153:223–239

    Google Scholar 

  • Samuels B (1935) Pathologic changes in the anterior half of the globe in obstruction in central vein or retina. Arch Ophthalmol 13:404–418

    Google Scholar 

  • Scuderi J, Blumenkranz MS, Blankenship G (1982) Regression of diabetic rubeosis iridis following successful surgical reattachment of the retina by vitrectomy. Retina 2:193–196

    Google Scholar 

  • Shabo A, Maxwell D, Shintaku P, Kreiger A, Straatsma BR (1977) Experimental immunogenic rubeosis iridis. Invest Ophthalmol Vis Sci 16:343–352

    Google Scholar 

  • Stefanson E, Landers MB, Wolbarsht ML, Klintworth GK (1984) Neovascularization of the iris: an experimental model in cats. Invest Ophthalmol Vis Sci 25:361–364

    Google Scholar 

  • Still WJS, Dennison S (1974) The arterial endothelium of hypertensive rat. Arch Pathol Lab Med 92:337–342

    Google Scholar 

  • Virdi PS, Hayreh SS (1982) Ocular neovascularization with retinal vascular occlusion. I. Association with experimental retinal vein occlusion. Arch Ophthalmol 100:331–341

    Google Scholar 

  • Weiss DI, Leopold IH (1961) Prognosis of secondary glaucoma following retinal artery occlusion. Am J Ophthalmol 51:793–796

    Google Scholar 

  • Wise GN (1956) Retinal neovascularizations. Trans Am Ophthalmol Soc 54:720–826

    Google Scholar 

  • Yoneya S, Tso A Numaga T, Yamazaki S, Tso MOM (1982) Rubeosis iridis in kittens with retrolental fibroplasia: a clinical, EM and SEM study, abstracted. Invest Ophthalmol Vis Sci [Suppl] 22:6

    Google Scholar 

  • Zion V, Goodside V (1974) Anterior segment ischemia with ischemic optic neuropathy. Surv Ophthalmol 19:19–30

    Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, University of Illinois, Chicago, Illinois, USA

    Gholam A. Peyman, Motilal Raichand, Claudio P. Juarez & Steven Reinglass

  2. Department of Pediatrics, University of Illinois, Chicago, Illinois, USA

    Eunice John

Authors
  1. Gholam A. Peyman
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  2. Motilal Raichand
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  3. Claudio P. Juarez
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  4. Steven Reinglass
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  5. Eunice John
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Additional information

Supported in part by core grant 1P3EY01792 from the National Institute of Health, Bethesda, Maryland, and internal support grant 58124

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Peyman, G.A., Raichand, M., Juarez, C.P. et al. Hypotony and experimental rubeosis iridis in primate eyes. Graefe's Arch Clin Exp Ophthalmol 224, 435–442 (1986). https://doi.org/10.1007/BF02173359

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  • DOI: https://doi.org/10.1007/BF02173359

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