Abstract
Subcutaneously administered calcium chloride and dibutyloxalate solutions produce calcium-oxalate retinopathy in rabbits that is demonstrable ophthalmoscopically and histologically, with remarkable impairment of the electroretinogram, whereas orally administered cystine seems to be inefficient. Orally administered tyrosine induces transitory pathological ERG signals in rabbits.
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References
Adams DR (1930) The nature of ocular lesions produced experimentally by naphthalene. Br J Ophthalmol 14:49–60
Albert DM, Bullock JD, Lahav M, Caine R (1975) Flecked retina secondary to oxalate crystals from methoxyflurane anesthesia: clinical and experimental studies. Trans Am Acad Ophthalmol 79:817–826
Besio R, Meerhoff E, Laza J, Venturini A (1983) Oxalosis. Am J Ophthalmol 95:397–398
Bullock JD, Albert DM (1975) Flecked retina. Appearance secondary to oxalate crystals from methoxyflurane anesthesia. Arch Ophthalmol 93:26–31
Bullock JD, Albert DM, Skinner HCW, Miller WH, Galla JH (1974) Calcium oxalate retinopathy associated with general oxalosis: X-ray diffraction and electron microscopic studies of crystal deposits. Invest Ophthalmol 13:256–265
Caine R, Albert DM, Lahav M, Bullock J (1975) Oxalate retinopathy: an experimental model of flecked retina. Invest Ophthalmol 14:359–363
Donaldson DD (1965) Cystinosis with extensive choroidal involvement. Arch Ophthalmol 74: 868
Fielder AR, Garner A, Chambers TL (1980) Ophthalmic manifestations in primary oxalosis. Br J Ophthalmol 64:782–788
François J, Hanssens M, Coppieters R, Evens L (1972) Cystinosis. A clinical and histologic study. Am J Ophthalmol 73:643–650
Frazier PD, Wong VG (1968) Cystinosis. Histologic and crystallographic examination of crystals in eye tissues. Arch Ophthalmol 80:87–91
Friedman AH, Charles NC (1974) Retinal oxalosis in two diabetic patients. Am J Ophthalmol 78:189–195
Haddad R, Witzmann K, Braun O (1979) Metastatic calcification to the peripheral fundus in chronic renal failure. Ophthalmologica 179:178–183
Hanhart E (1947) Neue Sonderformen von Keratosis palmo-plantaris, u.a. eine regelmäßig dominante mit systematisierten Lipomen, ferner 2 einfach-rezessive mit Schwachsinn und z.T. mit Hornhautveränderungen des Auges (Ektodermalsyndrom). Dermatologica 94:286–308
Hockaday TDR, Clayton JE, Frederick EW, Smith LH (1964) Primary hyperoxaluria. Medicine 43:315–345
Jensen OA (1975) Calcium oxalate crystals localized in the eye. Acta Ophthalmol (Copenh) 53: 187–196
Richner H (1938) Hornhautaffektion bei Keratoma palmare et plantare hereditarium. Klin Monatsbl Augenheilkd 100:580–588
Richard G, Kroll P (1983) Netzhautveranderungen bei Zystinose. Ophthalmologica 186:211–218
Richard G, Promesberger H (1982) Augenveränderungen bei Oxalose. Ophthalmologica 185:32–36
Sanderson RO, Kuwabara T, Stark WJ, Wong VG (1974) Cystinosis. A clinical, histopathologic and ultrastructural study. Arch Ophthalmol 92:270–274
Timm G (1963) Oxalose und Auge. Ophthalmologica 146:1–8
Timm G (1976) Das Krankheitsbild der Retinopathia oxalogenica. Klin Monatsbl Augenheilkd 168:537–543
Toussaint D, Verstreeten P, Goffin P, Vaulanduyt P, Jedwab J, Legrand JM (1976) Hyperoxalurie primaire. Etude clinique, histologique et cristallographique des lésions oculaires. Arch Ophthalmol (Paris) 36:97–112
Wong VG, Lietman PS, Seegmiller JE (1967) Alterations of pigment epithelium in cystinosis. Arch Ophthalmol 77:361–369
Zak TA, Bunic R (1983) Primary hereditary oxalosis retinopathy. Arch Ophthalmol 101:78
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Weber, U., Sons, H.U., Hennekes, R. et al. Experimental calcium oxalate retinopathy compared with cystine- and tyrosine-induced retinal damage. Graefe's Arch Clin Exp Ophthalmol 224, 414–418 (1986). https://doi.org/10.1007/BF02173355
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DOI: https://doi.org/10.1007/BF02173355