Recurrent multiple-branch retinal arteriolar occlusions in a patient with protein C deficiency

  • Michael E. Nelson
  • John F. Talbot
  • F. Eric Preston
Clinical Investigations


A 34-year-old woman is presented who has recurrent, multiple, retinal arteriolar occlusions associated with a deficiency in protein C, a vitamin K-dependent anticoagulant. Protein C is a naturally occurring anticoagulant and if there is a deficiency, it can lead to episodes of thrombosis; the deficiency can be acquired or congenital. This is the first documented case of retinal arteriolar occlusion associated with a congenital deficiency of this protein. The mechanism for arteriolar occlusion in this patient is discussed, and whilst the role of protein C deficiency remains presumptive, it is strongly implicated.


Public Health Documented Case Retinal Arteriolar Congenital Deficiency Arteriolar Occlusion 
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Copyright information

© Springer-Verlag, Berlin Heidelberg 1989

Authors and Affiliations

  • Michael E. Nelson
    • 1
  • John F. Talbot
    • 1
  • F. Eric Preston
    • 2
  1. 1.Department of OphthalmologyRoyal Hallamshire HospitalSheffieldUK
  2. 2.Department of HaematologyRoyal Hallamshire HospitalSheffieldUK

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