Summary
High doses of Muscarine have only peripheral para-sympathomimetic action in the cat. Even with toxic doses (up to 100µg/kg) the atropinized animal shows no blockade of sympathetic and parasympathetic ganglia or nerve-muscle transmission. Inhibition of Cholinesterase enhances Muscarine activity tenfold, suggesting that Muscarine is transformed in the body into an active Acetylester.
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Waser, P.G. Fehlende ganglionäre (nikotinische) Wirkung des Muscarins. Experientia 11, 452–453 (1955). https://doi.org/10.1007/BF02172558
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DOI: https://doi.org/10.1007/BF02172558