Host andPorphyromonas gingivalis proteinases in periodontitis: A biochemical model of infection and tissue destruction

Summary

Periodontitis is an excellent model of local tissue destruction due to the uncontrolled action of host and microbial proteinases. Although host enzymes are responsible for direct degradation of connective tissue, proteinases from the periodontopathogenic bacteriumPorphyromonas gingivalis are able to activate the kallikrein/kinin cascade, disrupt coagulation, and activate complement-mediated chemotaxis. Since the hallmarks of adult onset of periodontitis include infection by this pathogen, bleeding, increased crevicular flow, and neutrophil accumulation, investigations of this disease at a biochemical level indicate a major role for bacterial proteinases in infections byP. gingivalis.

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Potempa, J., Pike, R. & Travis, J. Host andPorphyromonas gingivalis proteinases in periodontitis: A biochemical model of infection and tissue destruction. Perspectives in Drug Discovery and Design 2, 445–458 (1995). https://doi.org/10.1007/BF02172037

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Key words

  • Proteolytic enzymes
  • Gingipain
  • Periodontal diseases
  • Bacterial infection
  • Inflammation