The HIV gp120-CD4 interaction: A target for pharmacological or immunological intervention?

Summary

The gp120-CD4 interaction is the initial stage in the infection cycle of CD4+ cells by HIV. It is therefore a logical target for pharmacological or immunological intervention. We review what is known about the gp120-CD4 binding reaction and the structures of the interacting ligands. We then discuss previous attempts to inhibit this interaction using antibodies and drugs, assess why such attempts have failed so far in vivo, and suggest future strategems.

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Moore, J.P., Sweet, R.W. The HIV gp120-CD4 interaction: A target for pharmacological or immunological intervention?. Perspectives in Drug Discovery and Design 1, 235–250 (1993). https://doi.org/10.1007/BF02171665

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Key words

  • HIV
  • gp120
  • CD4
  • gp120-CD4 interaction
  • Anti-gp120 antibodies
  • HIV pharmacology
  • HIV therapy