Perspectives in Drug Discovery and Design

, Volume 1, Issue 1, pp 69–83 | Cite as

The specificity of the HIV-1 protease

  • Steve C. Pettit
  • Scott F. Michael
  • Ronald Swanstrom
Perspectives

Summary

The protease of HIV-1 is able to recognize many different sequences as substrates. Despite the diversity of these sequences, some of the determinants of HIV-1 protease specificity have been clarified by recent studies. These studies include the examination of known processing-site sequences, the use of polypeptides and native protein as substrates in vitro, and structural analyses of protease with bound polypeptide-based inhibitors. Mutations of the HIV-1 protease also have the potential to alter its specificity.

Key words

Processing Proteinase Retrovirus 

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Copyright information

© ESCOM Science Publishers B.V 1993

Authors and Affiliations

  • Steve C. Pettit
    • 1
  • Scott F. Michael
    • 1
  • Ronald Swanstrom
    • 1
    • 2
  1. 1.Lineberger Comprehensive Cancer CenterUniversity of North Carolina at Chapel HillChapel HillUSA
  2. 2.Department of Biochemistry and BiophysicsUniversity of North Carolina at Chapel HillChapel HillUSA

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