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Increased inactivation of polysaccharide phosphorylase in liver homogenates from rats treated with 3,5,3′-triiodo-l-thyronine

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Riassunto

L'attività polisaccaride fosforilasica presente negli omogenati di fegato dei ratti trattati per 3 giorni con T-3 è sensibilmente diminuita; sono invece nettamente aumentate, in assenza di fluoruro, la trasformazione della formaa inb e, in presenza di fluoruro, l'inattivazione irreversibile dell'enzima. Nel fegato degli animali ipertiroidei la diminuzione dell'attività polisaccaride fosforilasica non sarebbe però dovuta all'esaltata inattivazione, ma alla minore concentrazione dell'enzima stesso.

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Authors and Affiliations

  1. Istituto di Fisiologia Generale dell'Università di Genova, Italy

    V. Martini, M. Orunesu & E. Fugassa

Authors
  1. V. Martini
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  2. M. Orunesu
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  3. E. Fugassa
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Additional information

Dedicated to Prof.A. v. Muralt on the occasion of his 60th birthday.

The following abbreviations are used: ATP, adenosine triphosphate; PPh, polysaccharide phosphorylase; IE, inactivating enzyme or phosphorylase phosphatase; Tris, Tris (hydroxymethyl) aminomethane; Pi, inorganic phosphate; T-3, 3,5,3′-triiodo-l-thyronine.

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Martini, V., Orunesu, M. & Fugassa, E. Increased inactivation of polysaccharide phosphorylase in liver homogenates from rats treated with 3,5,3′-triiodo-l-thyronine. Experientia 19, 423–424 (1963). https://doi.org/10.1007/BF02171526

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  • DOI: https://doi.org/10.1007/BF02171526

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