Experientia

, Volume 17, Issue 2, pp 76–76 | Cite as

6-Hydroxylation: An important metabolic route for α-methyltryptamine

  • S. Szara
Kurze Mitteilungen

Keywords

Metabolic Route 

Zusammenfassung

Der Stoffwechsel der psychotropischen Verbindung α-Methyltryptamin wurde untersucht. Die drei hauptsächlichsten Metabolite wurdenin vitro undin vivo als 6-Hydroxy-α-methyltryptamin, 3-Indolylaceton und 6-Hydroxy-3-indolylaceton identifiziert.

References

  1. 1.
    H. B. Murphree, Jr., E. H. Jenney, andC. C. Pfeiffer, The Pharmacologist2, 64 (1960).Google Scholar
  2. 2.
    S. Szara, unpublished observation.Google Scholar
  3. 3.
    S. Szara, E. Hearst, andF. Putney, Fed. Proc.19, 23 (1960).Google Scholar
  4. 4.
    W. G. Van Meter, G. F. Ayala, E. Costa, andH. E. Himwich, Fed. Proc.19, 265 (1960).Google Scholar
  5. 5.
    M. E. Greig, R. A. Walk, andA. J. Gibbons, J. Pharm. exp. Therap.127, 110 (1959).Google Scholar
  6. 6.
    A. Yuwiler, E. Geller, andS. Eiduson, Arch. Biochem. Biophys.80, 162 (1959).Google Scholar
  7. 7.
    J. Axelrod, J. biol. Chem.214, 753 (1955).Google Scholar
  8. 8.
    J. B. Brown, H. B. Henbest, andE. R. H. Jones, J. chem. Soc.1952, 3172.Google Scholar
  9. 9.
    S. Szara andJ. Axelrod, Exper.15, 216 (1959).Google Scholar
  10. 10.
    Since we usedd, l-αMT (synthetized according to the method ofE. H. P. Young, J. chem. Soc.1958, 3496), it is very probable that the bulk of the unchanged compound is thel-isomer not attacked by the stereospecific enzyme (see Ref.7).Google Scholar
  11. 11.
    E. Hearst andS. Szara, Amer. Psychologist15, 476 (1960).Google Scholar

Copyright information

© Birkhäuser Verlag 1961

Authors and Affiliations

  • S. Szara
    • 1
  1. 1.Clinical Neuropharmacology Research CenterWashington (D.C.)

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