Chinese medicine, Coix seeds increase peripheral cytotoxic T and NK cells
- 128 Downloads
Coix seeds, a Chinese medicine have been used in Japan and reported to be effective in patients with verruca vulgaris and verrucae planae juveniles. We investigated thein vivo effects on lymphocyte subsets in seven healthy volunteers who took six tablets of Coix seeds three times a day (a typical dose) for four weeks. Leukocyte counts and the percentage of total lymphocytes did not change but the percentages of CD3−CD56+ cells and CD16+CD57− cells increased significantly. These results indicate that Coix seeds increase peripheral cytotoxic lymphocytes and may be effective to viral infection through the enhancement of cytotoxic activity.
Key wordsChinese medicine Coix seeds cytotoxic T cell natural killer cell
Unable to display preview. Download preview PDF.
- 1.Otsuka H, Hirai Y, Nagao T et al. Anti-inflammatory activity of benzoxazinoids from roots of Coix Lachryma-Jobi var. Ma-yuen. J Nat Prod 1988; 51: 74–9.Google Scholar
- 2.Ukita T, Tanimura A. Studies on the anti-tumor component in the seeds of Coix Lachryma-Jobi L. var. Ma-yuen Stapf. 1. Isolation and anti-tumor activity of coixenolide. Chem Pharm Bull 1961; 11: 43–6.Google Scholar
- 3.Lever WF, Schaumburg-Lever G. Diseases caused by viruses. In: Histopathology of the Skin, 7th ed. Philadelphia: JB Lippincott, 1990; 411–3.Google Scholar
- 4.Irisawa G. Effect of Coix seeds in verruca vulgaris and verrucae planae juveniles. Kanpokenkyu (in Japanese) 1964; 2: 42–7.Google Scholar
- 5.Iwatani Y, Amino N, Hidaka Y et al. Decreases in αβ T cell receptor negative T cells and CD8 cells, and an increase in CD4−CD8+ cells in active Hashimoto's disease and subacute thyroiditis. Clin Exp Immunol 1992; 87: 444–9.Google Scholar
- 6.Lanier LL, Le AM, Phillips JH et al. Subpopulation of human natural killer cells defined by expression of the Leu-7 (HNK-1) and Leu-11 (NK-15) antigens. J Immunol 1983; 131: 1789–96.Google Scholar
- 7.Lanier LL, Le Am, Civin CI et al. The relation of CD16(Leu-11) and Leu-19(NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes. J Immunol 1986; 136: 4480–6.Google Scholar
- 8.Zinkernagel RM, Doherty PC. Immunological surveillance against altered self components by sensitized in lymphocytic choriomeningitis. Nature 1974; 251: 547–8.Google Scholar
- 9.Gillis S, Watson J. Interleukin-2 dependent culture of cytolytic T cell lines. Immunol Rev 1981; 54: 81–109Google Scholar
- 10.Herberman RB, Nunn ME, Lavrin DH. Natural cytotoxic reactivity of mouse lymphoid cells against syngeneic and allogeneic tumors. 1. Distribution of reactivity and specificity. Int J Cancer 1975; 16: 216–29.Google Scholar
- 11.Trinchieri G, Santoli D. Antiviral activity induced by culture lymphocytes with tumor-derived or virus-transformed cells. Enhancement of human natural killer activity by interferon and antagonistic inhibition susceptibility of target cells. J Exp Med 1978; 147: 1314–33.Google Scholar