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Die Beeinflussung der Thrombin-Fibrinogen-Reaktion durch Penicillin, Streptomycin und Aureomycin

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Summary

The influence of penicillin, streptomycin and aureomycin on the second phase of coagulation has been examined. The following results have been found:

  1. (1)

    Doses which are adequate to the therapeutic blood level do not influence the thrombin-fibrinogen reactionin vitro.

  2. (2)

    Doses which highly exceed the therapeutic blood level considerably prolong the thrombin-fibrinogen reaction by blocking thrombin.

  3. (3)

    This thrombin-blocking effect of antibiotics is suppressed by protamin sulphate up to a certain concentration.

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Authors and Affiliations

  1. II. medizinische Klinik der Universität Wien, Austria

    F. Mlczoch & H. Vinazzer

Authors
  1. F. Mlczoch
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  2. H. Vinazzer
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Mlczoch, F., Vinazzer, H. Die Beeinflussung der Thrombin-Fibrinogen-Reaktion durch Penicillin, Streptomycin und Aureomycin. Experientia 8, 150–152 (1952). https://doi.org/10.1007/BF02170225

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  • DOI: https://doi.org/10.1007/BF02170225

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