Blood-retinal and blood-aqueous barrier permeability, lens autofluorescence and transmission in insulin-dependent diabetic youngsters

  • Els van Wirdum
  • Jaap van Best
  • G. Jan Bruining
  • Carine de Beaufort
  • Jendo Oosterhuis
Clinical Investigations

Abstract

The permeability of the blood aqueous and blood retinal barrier, the lens transmission, and the lens autofluorescence were measured by fluorophotometry in 7 diabetic youngsters treated by conventional therapy (mean age, 10.9 ± 4.4 years), 9 diabetic youngsters treated by continuous s.c. insulin infusion (mean age, 12.3 ± 5.0 years), and 13 healthy controls (mean age, 12.4 ± 5.1 years). The mean permeability value for the blood retinal barrier of the diabetic juveniles did not differ significantly from that of the controls (P > 0.4), and no correlation with metabolic control (HbAlc) or duration of diabetes was found (P > 0.1). No differences in lens transmission larger than 4% were found. The mean value of lens autofluorescence corrected for normal age-dependency was found to correlate with the metabolic control: an increase of mean HbAlc by 1% resulted in an extra increase of autofluorescence by 11% (P = 0.002). This result suggests that good metabolic control can suppress excess lens autofluorescence, a precursor of cataract.

Keywords

Public Health Permeability Cataract Metabolic Control Conventional Therapy 

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Copyright information

© Springer-Verlag 1989

Authors and Affiliations

  • Els van Wirdum
    • 1
  • Jaap van Best
    • 1
  • G. Jan Bruining
    • 2
  • Carine de Beaufort
    • 2
  • Jendo Oosterhuis
    • 1
  1. 1.Department of OphthalmologyLeiden University Medical CenterLeidenThe Netherlands
  2. 2.Sophia Children's Hospital, University HospitalRotterdamThe Netherlands

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