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Fucosidosis: Ultrastructural study of the eye in an adult

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Abstract

The ocular histopathological and ultrastructural features of fucosidosis in a man who survived to the age of 25 years are reported. Virtually all of the cells of the eye contained cytoplasmic, membrane-bound, and confluent areas of fibrillogranular and multilaminated material. The most striking accumulations were present within the endothelial cells lining blood vessels and corneal endothelium, and the least amount was present in the uveal melanocytes.

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Authors and Affiliations

  1. Eye Pathology Laboratory, Wilmer Ophthalmological Institute, 600 N. Wolfe Street, Baltimore, Md, USA

    Motohiro Hoshino, Terrence P. O'Brien, Zenaida C. de la Cruz & W. Richard Green

  2. Department of Pathology, The Johns Hopkins Medical Institutions, 600 N. Wolfe Street, Baltimore, Md, USA

    Jan M. McDonnell & W. Richard Green

Authors
  1. Motohiro Hoshino
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  2. Terrence P. O'Brien
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  3. Jan M. McDonnell
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  4. Zenaida C. de la Cruz
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  5. W. Richard Green
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Supported in part by N.E.I. Core Grant EY 01765-11

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Hoshino, M., O'Brien, T.P., McDonnell, J.M. et al. Fucosidosis: Ultrastructural study of the eye in an adult. Graefe's Arch Clin Exp Ophthalmol 227, 162–171 (1989). https://doi.org/10.1007/BF02169791

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  • DOI: https://doi.org/10.1007/BF02169791

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