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Linkage analysis in granular corneal dystrophy (Groenouw I), Schnyder's crystalline corneal dystrophy, and Reis-Bücklers' corneal dystrophy

  • Clinical Investigations
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Abstract

Tight linkage was excluded for 8 markers in 37 blood relatives from 3 families, 29 of whom had granular corneal dystrophy (Groenouw I). Inconclusive results were obtained for linkage with four marker loci. The highest positive LOD score was 0.57 for linkage between glutamic pyruvic transaminase and granular corneal dystrophy. Tight linkage was excluded for glyoxalase-1 in eight individuals from one family with Schnyder's crystalline corneal dystrophy. Results were inconclusive for another six markers. Positive LOD scores were obtained for linkage with adenylate-kinase 1 and the ABO blood group, with values of 1.16 and 0.67, respectively. Among six blood relatives with Reis-Bücklers' corneal dystrophy, the highest positive LOD score was 1.17 for linkage with mitochondrial malic enzyme. For another six markers informative for linkage analysis, the results were inconsistent.

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Authors and Affiliations

  1. Institut für Anthropologie und, Humangenetik der Universität, Wilhelmstrasse 27, D-7400, Tübingen, Federal Republic of Germany

    Jost Kömpf & Horst Ritter

  2. Universitäts-Augenklinik, Schleichstrasse 12, D-7400, Tübingen, Federal Republic of Germany

    Walter Lisch & Egon G. Weidle

  3. Institut für Medizinische Statistik, Dokumentation und Datenverarbeitung der Universität, Sigmund-Freud-Strasse 25, D-5300, Bonn, Federal Republic of Germany

    Max P. Baur

Authors
  1. Jost Kömpf
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  2. Horst Ritter
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  3. Walter Lisch
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  4. Egon G. Weidle
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  5. Max P. Baur
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Additional information

This study was conducted with support from the Deutsche Forschungsgemeinschaft (Th 370/2-1, Ba 660/5-3)

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Kömpf, J., Ritter, H., Lisch, W. et al. Linkage analysis in granular corneal dystrophy (Groenouw I), Schnyder's crystalline corneal dystrophy, and Reis-Bücklers' corneal dystrophy. Graefe's Arch Clin Exp Ophthalmol 227, 538–540 (1989). https://doi.org/10.1007/BF02169448

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  • DOI: https://doi.org/10.1007/BF02169448

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