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Vasoconstrictive effect of topical timolol on human retinal arteries

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Abstract

Timolol is widely used in glaucoma treatment without sufficient knowledge of its vascular retinal effects. In this study, we measured the retinal vessel diameters before and after instillation of 0.5% timolol twice daily in one eye for 1 week, using photographic enlargements (×44). A total of 12 normal, Caucasian subjects aged 25–39 years (average, 30.6 ± 4.2 years) participated in this study. In all, 75% of the subjects had a diminution of retinal arterial size in the treated eye. The mean arterial diametric decrease was 4.1% in treated eyes compared with both untreated eyes and pretreatment values of treated eyes. These diminutions were statistically significant according to Student's pairedt-test (P < 0.05). No statistical difference was found in venous diameters (t = −0.065). Results showed that 0.5% timolol may have a vasoconstrictive effect on the retinal arteries of normal human subjects after 1 week of unilateral instillation twice daily. We suggest that this arterial vasoconstriction could be caused by the effect of timolol on the vascular beta-2 receptors. Further investigations are warranted to determine whether timolol also acts on ciliary arteries and whether arterial vasoconstriction participates in lowering intraocular pressure.

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References

  1. Airaksinen PJ, Alanko HI (1983) Vascular effects of timolol and pilocarpine in the iris. A simultaneous bilateral fluorescein angiographic study. Acta Ophthalmol 61:195–205

    Google Scholar 

  2. Anonym (1981) Adverse systemic effects from ophthalmic drugs. Med Lett Drugs Ther 24:53–54

  3. Anonym (1982) Phenylephrine eye drops and beta-blockers. Med Lett Drugs Ther 24:70

  4. Bill A (1973) The role of ciliary blood flow and ultrafiltration in aqueous humor formation. Exp Eye Res 16:287–298

    PubMed  Google Scholar 

  5. Brodwall J, Fischbarg J (1982) The hydraulic conductivity of rabbit ciliary epithelium in vitro. Exp Eye Res 34:121–129

    PubMed  Google Scholar 

  6. Coakes RL, Brubaker RF (1978) The mechanism of timolol in lowering intraocular pressure in the normal eye. Arch Ophthalmol 96:2045–2048

    PubMed  Google Scholar 

  7. Cole DF (1977) Secretion of aqueous humor. Exp Eye Res 25 [Suppl]:161–176

    PubMed  Google Scholar 

  8. Colloton E, Perkins ES (1986) The effect of timolol on the intraocular pulse pressure. Invest Ophthalmol Vis Sci 27 [Suppl]:102

    Google Scholar 

  9. Cruickshank JM (1980) The clinical importance of cardioselectivity and lipophilicity in beta blockers. Am Heart J 100:160–178

    PubMed  Google Scholar 

  10. Demailly Ph, Aubrier G, Abadie P (1985) Timolol et pronostic fonctionnel périmètrique du glaucome primitif à angle ouvert. J Fr Ophthalmol 8:383–388

    Google Scholar 

  11. Demmler N, Mueller-Bardorff G (1983) Zunahme von Gesichtsfelddefekten unter Timolol-Langzeitbehandlung bei Patienten mit Weitwinkelglaukom — Beobachtung in der augenärztlichen Praxis. Klin Monatsbl Augenheilkd 183:53–58

    PubMed  Google Scholar 

  12. Denis Ph (1989) Récepteurs bêta-adrenergiques vasculaires rétiniens chez l'homme. Ophtalmologie 3:62–64

    PubMed  Google Scholar 

  13. Drance SM (1985) Low-tension glaucoma. Arch Ophthalmol 103:1131–1133

    PubMed  Google Scholar 

  14. Drance SM, Flammer J (1984) Some effects of antiglaucoma drugs on visual function. In: Drance SM, Neufeld AH (eds) Applied pharmacology in medical treatment. Grune and Stratton, New York, pp 569–576

    Google Scholar 

  15. Drayer JI, Weber MA, Frankfort PP (1985) Disparate response of blood pressure to adrenergic stimuli during beta blockade. Gen Pharmacol 16:229–234

    PubMed  Google Scholar 

  16. Ferrari-Dileo G (1988) Beta-1 and beta-2 adrenergic binding sites in bovine retina and retinal blood vessels. Invest Ophthalmol Vis Sci 29:695–699

    PubMed  Google Scholar 

  17. Flammer J, Drance SM (1983) The effect of a number of glaucoma medications on the differential light threshold. Doc Ophthalmol Proc Ser 35:145–148

    Google Scholar 

  18. Flammer J, Robert Y, Gloor B (1986) Influence of pindolol and timolol treatment on the visual fields of glaucoma patients. J Ocular Pharmacol 2:305–311

    Google Scholar 

  19. Ganong WF (1985) Cardiovascular regulatory mechanisms. In: Ganong WF (ed) Review of medical physiology. Lange Medical, Los Altos, p 487

    Google Scholar 

  20. Grunwald JE (1986) Effect of timolol on the human retinal circulation. Invest Ophthalmol Vis Sci 27:1713–1719

    PubMed  Google Scholar 

  21. Holmin C, Krakau CET (1982) Short-term effect of timolol in chronic glaucoma. Acta Ophthalmol 60:337–346

    Google Scholar 

  22. Jay WM, Aziz MZ, Green K (1984) Effect of topical epinephrine and timolol on ocular and optic nerve blood flow in phakic and aphakic rabbit eyes. Curr Eye Res 3:1199–1202

    PubMed  Google Scholar 

  23. Katz IM, Kulaga SF, Gould AL, Miller IM, Clineschmidt CM, Wittreich JM (1987) Long-term tolerability and efficacy of timolol ophthalmic solution. Glaucoma 9:84–88

    Google Scholar 

  24. Leenen FHH, Redmond DP, McDonald RH Jr (1975) Alpha- and beta-adrenergic induced renin release in man. Clin Pharmacol Ther 18:31–38

    PubMed  Google Scholar 

  25. Lobstein A, Flament J (1982) Timolol-Nachwirkung bei erhöhtem Augendruck. Klin Monatsbl Augenheilkd 180:27–28

    PubMed  Google Scholar 

  26. Martin X (1987) Agonistes cholinergiques locaux et réactions systémiques paradoxales. J Fr Ophthalmol 10:129–133

    Google Scholar 

  27. Martin X, Lichter PR (1988) Neuropharmacologic control of intraocular pressure. In: Shields MB, Pollack IP, Kolker AE (eds) Perspectives in glaucoma, transactions of first scientific meeting of the American Glaucoma Society. Slack, Thorofare, pp 113–123

    Google Scholar 

  28. Merte HJ, Merkle W (1980) Timolol-Augentropfen in der Glaukombehandlung. Ergebnisse einer Langzeitstudie. Klin Monatsbl Augenheilkd 177:562–571

    PubMed  Google Scholar 

  29. Mindel J (1987) Editor's note. Surv Ophthalmol 31:323

    Google Scholar 

  30. Mostaghim R, Maddox YT, Ramwell PW (1986) Endothelial potentiation of relaxation response to beta adrenoceptor blocking agents. J Pharmacol Exp Ther 239:797–801

    PubMed  Google Scholar 

  31. Myers MG (1984) Beta adrenoceptor antagonism and pressor response to phenylephrine. Clin Pharmacol Ther 36:57–63

    PubMed  Google Scholar 

  32. Nelson WL, Frauenfelder FT, Sills JM, Arrowsmith JB, Kuritsky JN (1986) Adverse respiratory and cardiovascular events attributed to timolol ophthalmic solution, 1978– 1985. Am J Ophthalmol 102:606–611

    PubMed  Google Scholar 

  33. Neufeld AH (1979) Experimental studies on the mechanism of action of timolol. Surv Ophthalmol 23:363–370

    PubMed  Google Scholar 

  34. Neufeld AH (1981) Epinephrine and timolol: how do these drugs lower intraocular pressure? Ann Ophthalmol 13:1109–1111

    PubMed  Google Scholar 

  35. Nielsen NV, Eriksen JS (1979) Timolol in maintenance treatment of ocular hypertension and glaucoma. Acta Ophthalmol 57:1070–1077

    Google Scholar 

  36. Novack GD (1987) Ophthalmic beta-blockers since timolol. Surv Ophthalmol 31:307–327

    PubMed  Google Scholar 

  37. Pakalnis VA, Rustgi AK, Stefansson E, Wolbarsht ML, Landers MB (1987) The effect of timolol on anterior chamber oxygenation. Ann Ophthalmol 19:298–300

    PubMed  Google Scholar 

  38. Phillips CI, Bartholomew RS, Kazi G, Schmitt CJ, Vogel R (1981) Penetration of timolol eye drops into human aqueous humour. Br J Ophthalmol 65:593–595

    PubMed  Google Scholar 

  39. Pillunat LE, Stodtmeister R, Wilmanns I, Metzner D (1986) Effect of timolol on optic nerve head autoregulation. Ophthalmologica 193:146–153

    PubMed  Google Scholar 

  40. Richard G, Weber J (1987) Der Einfluß der Betablocker Timolol und Pindolol auf die retinale Haemodynamik — eine videoangiographische Studie. Klin Monatsbl Augenheilkd 190:34–39

    PubMed  Google Scholar 

  41. Van Buskirk EM (1980) Adverse reactions from timolol administration. Ophthalmology 87:447–450

    PubMed  Google Scholar 

  42. Weekers R, Collignon-Brach J (1981) Bêta-stimulants et bê ta-bloquants. Leur place dans le traitement médical du glaucome à angle ouvert. J Fr Ophthalmol 4: 149–155

    Google Scholar 

  43. Wilffert B, Davidesko D, De Jonge A, Thoolen M, Timmermans P, Van Zwieten P (1983) Role of ganglionic M1 and M2 receptors in the neuronal control of the cardiovascular system of the normotensive rat as determined with pilocarpine. Eur J Pharmacol 95:109–116

    PubMed  Google Scholar 

  44. Wizerman A, Krey H (1981) Thermographische Untersuchungen zum Wirkungsmechanismus von Timolol. Klin Monatsbl Augenheilkd 178:190–193

    PubMed  Google Scholar 

  45. Yablonski ME, Zimmerman TJ, Waltman SR, Becker BA (1978) A fluorometric study of the effect of topical timolol on aqueous humor dynamics. Exp Eye Res 2:135–142

    Google Scholar 

  46. Yan HY, Chiou GCY (1987) Effects ofl-timolol,d-timolol, haloperidol and domperidone on rabbit retinal blood flow measured with laser Doppler method. Ophthalmic Res 19:45–48

    PubMed  Google Scholar 

  47. Zimmerman TJ, Harbin R, Pett M, Kaufman HE (1977) Timolol and facility of outflow. Invest Ophthalmol Vis Sci 16:623–624

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, University of Basel, Mittlere Strasse 91, CH-4065, Basel, Switzerland

    Xavier D. Martin & Paul A. Rabineau

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  1. Xavier D. Martin
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  2. Paul A. Rabineau
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Martin, X.D., Rabineau, P.A. Vasoconstrictive effect of topical timolol on human retinal arteries. Graefe's Arch Clin Exp Ophthalmol 227, 526–530 (1989). https://doi.org/10.1007/BF02169445

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  • DOI: https://doi.org/10.1007/BF02169445

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