Journal of Radioanalytical and Nuclear Chemistry

, Volume 155, Issue 4, pp 253–261 | Cite as

99mTc labeled ethylene-bis (valine) and ethylene-bis (α-alanine) and their preliminary biobistribution

  • E. Havránek
  • A. Bumbálová
  • P. Křenek
  • M. Strašák
  • M. Beláková
  • M. Komová
Article

Abstract

The preparation of99mTc-Sn-EBV and99mTC-Sn-EBA is described. Different parameters affecting the labeling efficiency (ligand concentration, pH, molar ligand: reducing agent ratio) as well as the time-dependent stability of labeled compounds were investigated. Preliminary biodistribution studies in Wistar rats showed accumulation of the above mentioned compounds in kidneys.

Keywords

Physical Chemistry Inorganic Chemistry Valine Ligand Concentration Biodistribution Study 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    A. Bumbálová, E. Havránek, M. Harangozó, P. Křenek, P. Butvin,J. Radioanal. Nucl. Chem., Lett., 137 (1989) 251.Google Scholar
  2. 2.
    E. Havránek, A. Bumbálová, M. Harangozó, P. Křenek,J. Radioanal. Nucl. Chem., Lett., 145 (1990) 413.Google Scholar
  3. 3.
    A. Bumbálová, E. Havránek, M. Harangozó, P. Křenek, S. Lübkeová,J. Radioanal. Nucl. Chem., Lett., 154 (1991) 53.Google Scholar
  4. 4.
    M. Strašák, F. Bachratý, J. Majer,Collect. Czech. Chem. Commun., 47 (1982) 210.Google Scholar
  5. 5.
    L. N. Schoenberg, D. W. Cooke, C. F. Liu,Inorg. Chem., 7 (1968) 2386.Google Scholar

Copyright information

© Akadémiai Kiadó 1991

Authors and Affiliations

  • E. Havránek
    • 1
  • A. Bumbálová
    • 1
  • P. Křenek
    • 1
  • M. Strašák
    • 1
  • M. Beláková
    • 1
  • M. Komová
    • 1
  1. 1.Department of Analytical Chemistry, Faculty of PharmacyComenius UniversityBratislavaČSFR

Personalised recommendations