Journal of Radioanalytical and Nuclear Chemistry

, Volume 164, Issue 2, pp 123–130 | Cite as

Synthesis of195mPt radiolabeled (−)-(R)-2-aminomethyl-pyrrolidine (1,1-cyclobutanedicarboxylato)-2-platinum(II) monohydrate using high performance liquid chromatography

  • K. Kawai
  • S. Takada
  • Y. Nakano
  • W. Ehrlich
  • H. Maki
  • M. Akaboshi
Article

Abstract

An experimental method is described for the synthesis of195mPt-radiolabeled (−)-(R)-2-aminomethylpyrrolidine (1,1-cyclobutanedicarboxylato)-2-platinum (II) (DWA2114R). An amount of 10 mg of 95% enriched194Pt was irradiated for 75 h in the hydraulic conveyer of the KUR at a thermal neutron flux of approximately 8.1×1013 n.cm−2.sec−1 and the195mPt-radiolabeled DWA2114R was purified using HPLC. The chemical yield is higher than 65%, its chemical purity is greater than 99.2%, the radiochemical purity is nearly 100%, and the specific activity is 6.7 MBq. mg−1 DWA2114R.

Keywords

Chromatography Physical Chemistry HPLC Platinum Inorganic Chemistry 

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Copyright information

© Akadémiai Kiadó 1992

Authors and Affiliations

  • K. Kawai
    • 1
  • S. Takada
    • 2
  • Y. Nakano
    • 1
  • W. Ehrlich
    • 3
  • H. Maki
    • 1
  • M. Akaboshi
    • 1
  1. 1.Research Reactor InstituteKyoto UniversitySennan, OsakaJapan
  2. 2.Drug Metabolism CenterChugai Pharmaceutical Co., Ltd.TokyoJapan
  3. 3.Robert Koch InstituteBerlin 65Germany

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