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Die Wirkung von Herzglykosiden und Kalzium auf den Kaliumtransport im Herzmuskel

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Summary

In isolated perfused guinea pig hearts, both strophanthin and calcium produced positive inotropic effects and contracture increasing with the concentration of the drugs. Strophanthin caused a net loss of potassium from the heart to the perfusing fluid whereas calcium did not interfer in the same way with potassium exchange. The data are consistent with the view that the positive inotropic effect of cardiac glycosides depends mainly on the increased intracellular calcium concentration, perhaps due to inhibition of the active potassium and sodium transport.

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Author notes

  1. F. Sulser

    Present address: National Heart Institute, Laboratory of Chemical Pharmacology, Bethesda, Maryland

Authors and Affiliations

  1. Pharmakologisches Institut der Universität Bern, Switzerland

    F. Sulser

Authors
  1. F. Sulser
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Sulser, F. Die Wirkung von Herzglykosiden und Kalzium auf den Kaliumtransport im Herzmuskel. Experientia 15, 97–99 (1959). https://doi.org/10.1007/BF02166693

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  • DOI: https://doi.org/10.1007/BF02166693

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