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Chromatographic and biological comparison of99mTc-DMSA prepared by direct labelling and ligand exchange reaction

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Abstract

99mTc-dimercaptosuccinic acid /DMSA/ is one of the most favourable agents used for renal scintigraphy. This radiopharmaceutical was prepared in two different ways: by direct labelling of tin/II/-dimercaptosuccinic acid and by ligand exchange reaction from99mTc-gluconate at tracer concentration of technetium under acidic condition. The complexes formed were compared using paper chromatography, thin layer chromatography, gel filtration and electrophoresis. Their biodistribution was studied on rats.

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Authors and Affiliations

  1. Institute of Isotopes of the Hungarian Academy of Sciences, P. O. Box 77, H-1525, Budapest, Hungary

    J. Imre

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  1. J. Imre
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Imre, J. Chromatographic and biological comparison of99mTc-DMSA prepared by direct labelling and ligand exchange reaction. Journal of Radioanalytical and Nuclear Chemistry Letters 87, 301–310 (1984). https://doi.org/10.1007/BF02165936

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  • DOI: https://doi.org/10.1007/BF02165936

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