Abstract
A series of substituted cinnamic acids labelled at the ring positions with deuterium or tritium has been easily obtained via the Doebner modification of Knoevenagel condensation reaction between labelled benzaldehyde derivatives and malonic acid in pyridine. The substituted benzaldehyde precursors were synthesized by isotope exchange method in deuterated or tritiated water at 80 °C in acidic medium. Ring-tritiated substituted cinnamic acids with specific activity ranging from 207 GBq /5.6 Ci/ mol−1 to 4366 GBq /118 Ci/ mol−1 was obtained using ca. 37 GBq /1 Ci/ of HTO.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
A.C. Neish, in: Biochemistry of Phenolic Compounds, Academic Press, New York, 1964;
T. Higuchi,Advan. Enzymol., 34 /1971/ 207.
K. Haider, S. Lim,J. Label. Compounds, 1 /1965/ 294;
P. Manitto, I. Monti, P. Gramatica, E. Sabbioni,J. Chem. Soc. Chem. Commun., /1973/ 563.
M. Herbert, G. Rochas, L. Pichat,J. Label. Compounds, 4 /1968/ 240;
J.F. De Bardeleben, L.C. Teng,J. Label. Compounds, 6 /1970/ 34;
H.M. Balba, G.G. Still,J. Label. Compounds, Radiopharm., 15 /1978/ 309.
K. Suzuki,Analyt. Biochem., 88 /1978/ 468.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Angelini, G., Speranza, M., Felici, M. et al. Preparation of substituted cinnamic acids labelled with deuterium and tritium at the ring positions. Journal of Radioanalytical and Nuclear Chemistry Letters 87, 283–289 (1984). https://doi.org/10.1007/BF02165934
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02165934